Unfaithful DNA polymerase caught in the act

Josef Jiricny

doi:10.1016/s1097-2765(04)00149-2

Unfaithful DNA polymerase caught in the act

Mol Cell. 2004 Mar 26;13(6):768-9. doi: 10.1016/s1097-2765(04)00149-2.

Author

Josef Jiricny¹

Affiliation

¹ Institute of Molecular Cancer Research, University of Zürich, August Forel-Strasse 7, CH-8008 Zurich, Switzerland.

PMID: 15053870
DOI: 10.1016/s1097-2765(04)00149-2

Abstract

The 3D structures of all 12 mispairs formed in the active site of a DNA polymerase help explain their differential effects on polymerase stalling and on translocation of the primer terminus to the enzyme's proofreading site.

MeSH terms

Base Pair Mismatch
Base Pairing
Base Sequence
Binding Sites
DNA-Directed DNA Polymerase / chemistry*
DNA-Directed DNA Polymerase / genetics
DNA-Directed DNA Polymerase / metabolism*
Exonucleases / metabolism
Nucleic Acid Conformation
Nucleic Acid Heteroduplexes
Translocation, Genetic

Substances

Nucleic Acid Heteroduplexes
DNA-Directed DNA Polymerase
Exonucleases