Abstract
Growth inhibitory activities and nutritional indices of catalpol (1), 8-O-acetylharpagide (2), and harpagide (3) were determinated in larvae and adults of Tribolium castaneum, respectively. Compound 1 produced a series of allelochemical effects probably related with the DNA synthesis. This iridoid possessed the highest inhibitory activity against DNA polymerase. Molecular orbital calculations suggest that a pi-pi charge transfer recognition model could explain the action of iridioids toward nucleic acid synthesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology*
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology*
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Insect Control*
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Iridoid Glucosides
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Iridoid Glycosides
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Iridoids / chemistry
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Iridoids / isolation & purification*
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Iridoids / pharmacology*
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Larva / drug effects
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Models, Molecular
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Molecular Structure
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Nucleic Acid Synthesis Inhibitors* / chemistry
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Nucleic Acid Synthesis Inhibitors* / isolation & purification*
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Nucleic Acid Synthesis Inhibitors* / pharmacology*
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Pyrans / chemistry
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Pyrans / isolation & purification*
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Pyrans / pharmacology*
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Tribolium / drug effects*
Substances
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Enzyme Inhibitors
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Glucosides
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Iridoid Glucosides
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Iridoid Glycosides
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Iridoids
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Nucleic Acid Synthesis Inhibitors
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Pyrans
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catalpol
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8-O-acetylharpagide
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harpagide