Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1

K Ohta; Y Nobukuni; H Mitsubuchi; T Ohta; T Tohma; Y Jinno; F Endo; I Matsuda

doi:10.1016/0378-1119(92)90234-g

Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1

Gene. 1992 Dec 15;122(2):387-8. doi: 10.1016/0378-1119(92)90234-g.

Authors

K Ohta¹, Y Nobukuni, H Mitsubuchi, T Ohta, T Tohma, Y Jinno, F Endo, I Matsuda

Affiliation

¹ Department of Pediatrics, Kumamoto University School of Medicine, Japan.

PMID: 1487156
DOI: 10.1016/0378-1119(92)90234-g

Abstract

Pit-1 is a pituitary-specific transcription factor that binds to and transactivates promoters of growth hormone- and prolactin-encoding genes. A chromosomal gene related to human Pit-1 isolated from human gene libraries was over 14 kb long and split into six exons. All of the splice donor and acceptor sites conformed to the GT/AG rule. The gene was mapped to human chromosome region 3p11.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 3
DNA
DNA-Binding Proteins / genetics*
Exons
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Molecular Sequence Data
Transcription Factor Pit-1
Transcription Factors / genetics*

Substances

DNA-Binding Proteins
POU1F1 protein, human
Transcription Factor Pit-1
Transcription Factors
DNA

Associated data

GENBANK/D11333
GENBANK/D11334
GENBANK/L02347
GENBANK/M79310
GENBANK/M81115
GENBANK/M81116
GENBANK/M81117
GENBANK/M81118
GENBANK/X65112
GENBANK/X65113