Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents

Farmaco. 2004 Jan;59(1):33-9. doi: 10.1016/j.farmac.2003.09.001.

Abstract

Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30-50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemical synthesis*
  • Anti-HIV Agents / pharmacology*
  • Cell Survival / drug effects
  • Cell Survival / physiology
  • Drug Evaluation, Preclinical
  • HIV-1 / drug effects
  • HIV-1 / growth & development
  • HIV-2 / drug effects
  • HIV-2 / growth & development
  • Humans
  • Molecular Structure
  • Reverse Transcriptase Inhibitors / chemical synthesis*
  • Reverse Transcriptase Inhibitors / pharmacology*
  • Structure-Activity Relationship
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / virology
  • Thiazoles / chemical synthesis*
  • Thiazoles / pharmacology*
  • Virus Replication / drug effects

Substances

  • Anti-HIV Agents
  • Reverse Transcriptase Inhibitors
  • Thiazoles