Synthesis and biological activity of N-Acylated ornithine analogues of daptomycin

Bioorg Med Chem Lett. 2003 Dec 1;13(23):4187-91. doi: 10.1016/j.bmcl.2003.07.019.

Abstract

N-Acylated ornithine analogues of daptomycin were synthesized and tested for their antibacterial efficacy.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology
  • Daptomycin / analogs & derivatives*
  • Daptomycin / chemical synthesis*
  • Daptomycin / pharmacology
  • Mice
  • Microbial Sensitivity Tests
  • Ornithine / analogs & derivatives*
  • Ornithine / chemical synthesis
  • Ornithine / pharmacology
  • Sepsis / drug therapy*
  • Staphylococcal Infections / drug therapy*
  • Staphylococcus aureus / pathogenicity

Substances

  • Anti-Bacterial Agents
  • Ornithine
  • Daptomycin