Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency

N Engl J Med. 2003 Nov 6;349(19):1821-8. doi: 10.1056/NEJMoa031178.

Authors

Harjit K Dadi¹, Amos J Simon, Chaim M Roifman

Affiliation

¹ Divisions of Immunology and Allergy and the Infection, Immunity, Injury and Repair Program, the Research Institute and the Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

PMID: 14602880
DOI: 10.1056/NEJMoa031178

No abstract available

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

B-Lymphocytes
Blotting, Western
CD3 Complex / genetics*
CD3 Complex / immunology
Consanguinity
Fatal Outcome
Female
Gene Expression
Humans
Immunohistochemistry
Infant
Infant, Newborn
Male
Oligonucleotide Array Sequence Analysis
Pedigree
Phenotype
Receptors, Antigen, T-Cell, alpha-beta / immunology
Receptors, Antigen, T-Cell, gamma-delta / immunology
Severe Combined Immunodeficiency / genetics*
Severe Combined Immunodeficiency / immunology*
Severe Combined Immunodeficiency / pathology
T-Lymphocytes / immunology*

Substances

CD3 Complex
CD3delta antigen
Receptors, Antigen, T-Cell, alpha-beta
Receptors, Antigen, T-Cell, gamma-delta