Differentially regulated malate synthase genes par...[Nucleic Acids Res. 1992]

SearchDatabase nameforSearch term

Advanced Search

Your browser version may not work well with NCBI's Web applications. More information here...

Display Show

All: 1

Review: 0

Click to change filter selection through MyNCBI.

1: Nucleic Acids Res. 1992 Nov 11;20(21):5677-86. Links

Differentially regulated malate synthase genes participate in carbon and nitrogen metabolism of S. cerevisiae.

Hartig A, Simon MM, Schuster T, Daugherty JR, Yoo HS, Cooper TG.

Institut fuer Allgemeine Biochemie der Universitaet, Wien, Austria.

We have isolated a second gene (MLS1), which in addition to DAL7, encodes malate synthase from S. cerevisiae. Expression of the two genes is specific for their physiological roles in carbon and nitrogen metabolism. Expression of MLS1, which participates in the utilization of non-fermentable carbon sources, is sensitive to carbon catabolite repression, but nearly insensitive to nitrogen catabolite repression. DAL7, which participates in catabolism of the nitrogenous compound allantoin, is insensitive to carbon catabolite repression, but highly sensitive to nitrogen catabolite repression. Results obtained with null mutations in these genes suggest that S. cerevisiae contains at least one and perhaps two additional malate synthase genes.

PMID: 1454530 [PubMed - indexed for MEDLINE]

PMCID: PMC334402

Expression of the DAL80 gene, whose product is homologous to the GATA factors and is a negative regulator of multiple nitrogen catabolic genes in Saccharomyces cerevisiae, is sensitive to nitrogen catabolite repression. [Mol Cell Biol. 1991]
Constitutive and carbon source-responsive promoter elements are involved in the regulated expression of the Saccharomyces cerevisiae malate synthase gene MLS1. [Mol Gen Genet. 1997]
Sequences of two adjacent genes, one (DAL2) encoding allantoicase and another (DCG1) sensitive to nitrogen-catabolite repression in Saccharomyces cerevisiae. [Gene. 1991]
ReviewGenetic regulation of nitrogen metabolism in the fungi. [Microbiol Mol Biol Rev. 1997]
ReviewNitrogen catabolite repression in Saccharomyces cerevisiae. [Mol Biotechnol. 1999]

Display Show

Differentially regulated malate synthase genes participate in carbon and nitrogen metabolism of S. cerevisiae.

Related Articles