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1: Gene. 1992 Oct 12;120(1):115-8.Click here to read Links

Characterization of the ilv-2 gene from Neurospora crassa encoding alpha-keto-beta-hydroxylacyl reductoisomerase.

Sista H, Bowman B.

Department of Biology, Sinsheimer Laboratories, University of California, Santa Cruz 95064.

We have isolated the cDNA and corresponding genomic DNA for the ilv-2 locus of Neurospora crassa. This gene encodes alpha-keto-beta-hydroxylacyl reductoisomerase (Ilv-2), required for the synthesis of isoleucine and valine. The gene contains four introns, maps to the right arm of chromosome V, and encodes a protein of 400 amino acids (aa). Alignment of the aa sequence of Ilv-2 with the two other known eukaryotic sequences encoding this enzyme reveals two conserved regions.

PMID: 1398116 [PubMed - indexed for MEDLINE]

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