Acetylation status using hydralazine in African hypertensives at Kenyatta National Hospital

East Afr Med J. 1992 Jul;69(7):406-8.

Abstract

In this study, the investigation of hydralazine acetylator phenotype was undertaken for the first time in African hypertensives at Kenyatta National Hospital. A total of 25 randomly selected patients with moderate to severe hypertension (diastolic pressure 105-130 mmHg), participated in the phenotyping study. The phenotyping was done by administering oral standard hydralazine dose of 150 mg/day in three divided doses. The 24 hour urinary MTP/hydralazine ratio was used to categorize patients into slow and fast acetylators. Of the patients studied 69.9% were slow acetylators while 30.4% were fast acetylators. The mean 24 hour urinary MTP/hydralazine ratio for slow acetylators was 1.01 +/- 0.95. This was significantly different from the fast acetylators where the mean 24 hour urinary MTP/hydralazine ratio was 10.6 +/- 4.4 (P < 0.001). The acetylator phenotyping divided the patients into two distinct populations and no further arbitrary method was required to divide the patients into either group.

MeSH terms

  • Acetylation
  • Administration, Oral
  • Adult
  • Aged
  • Arylamine N-Acetyltransferase*
  • Female
  • Gene Frequency
  • Hospitals, Public
  • Humans
  • Hydralazine / administration & dosage
  • Hydralazine / metabolism*
  • Hydralazine / urine
  • Hypertension / drug therapy*
  • Hypertension / epidemiology
  • Hypertension / genetics
  • Kenya / epidemiology
  • Male
  • Middle Aged
  • Phenotype*

Substances

  • Hydralazine
  • Arylamine N-Acetyltransferase