Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes

J Immunol. 1992 Jun 1;148(11):3618-23.

Abstract

The nucleotide sequence of a 7.2-kb segment containing the mouse IL-10 (mIL-10) gene was determined. Comparison to the mIL-10 cDNA sequence (Moore, K. W., et al. 1990. Science 248:1230; 250:494) revealed the presence of five exons that span approximately 5.1 kb of genomic DNA. The noncoding regions of the mIL-10 gene contain sequences that have been associated with transcriptional regulation of several cytokine genes. The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1
  • Gene Expression Regulation
  • Genes
  • Humans
  • Interleukin-10 / genetics*
  • Mice
  • Molecular Sequence Data
  • Oligodeoxyribonucleotides / chemistry
  • Open Reading Frames
  • Polymorphism, Restriction Fragment Length
  • Regulatory Sequences, Nucleic Acid
  • Restriction Mapping

Substances

  • Oligodeoxyribonucleotides
  • Interleukin-10

Associated data

  • GENBANK/M84340