Confirmation of the localization of the human GABAA receptor alpha 1-subunit gene (GABRA1) to distal 5q by linkage analysis

K J Johnson; T Sander; A A Hicks; A van Marle; D Janz; M J Mullan; B P Riley; M G Darlison

doi:10.1016/s0888-7543(05)80178-8

Confirmation of the localization of the human GABAA receptor alpha 1-subunit gene (GABRA1) to distal 5q by linkage analysis

Genomics. 1992 Nov;14(3):745-8. doi: 10.1016/s0888-7543(05)80178-8.

Authors

K J Johnson¹, T Sander, A A Hicks, A van Marle, D Janz, M J Mullan, B P Riley, M G Darlison

Affiliation

¹ Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, Imperial College, London, United Kingdom.

PMID: 1330891
DOI: 10.1016/s0888-7543(05)80178-8

Abstract

The GABAA receptor is the major inhibitory neurotransmitter receptor in the mammalian brain. To date, 14 genes that encode subunits of this receptor have been identified; these appear to be scattered throughout the human genome and are under investigation as candidate loci for a number of neurological and psychiatric disorders. We report here a highly polymorphic (dC-dA)n repeat within the human alpha 1-subunit gene (GABRA1). Typing of this marker in the Centre d'Etude du Polymorphisme Humain (CEPH) panel of families confirms the previous assignment of the GABRA1 locus to the distal portion of chromosome 5q by demonstrating linkage to the markers CRI-L45 (D5S61) (Zmax = 11.00, theta max = 0.15), CRI-V1022 (D5S54) (Zmax = 7.25, theta max = 0.20), and CRI-P148 (D5S72) (Zmax = 5.71, theta max = 0.24).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Cell Line
Chromosome Mapping
Chromosomes, Human, Pair 5*
DNA, Single-Stranded
Female
Genetic Linkage*
Humans
Male
Molecular Sequence Data
Pedigree
Polymorphism, Genetic
Receptors, GABA-A / genetics*
Repetitive Sequences, Nucleic Acid

Substances

DNA, Single-Stranded
Receptors, GABA-A