A new superfamily of protein-O-fucosyltransferases, alpha2-fucosyltransferases, and alpha6-fucosyltransferases: phylogeny and identification of conserved peptide motifs

Ivan Martinez-Duncker; Rosella Mollicone; Jean-Jacques Candelier; Christelle Breton; Rafael Oriol

doi:10.1093/glycob/cwg113

A new superfamily of protein-O-fucosyltransferases, alpha2-fucosyltransferases, and alpha6-fucosyltransferases: phylogeny and identification of conserved peptide motifs

Glycobiology. 2003 Dec;13(12):1C-5C. doi: 10.1093/glycob/cwg113. Epub 2003 Sep 9.

Authors

Ivan Martinez-Duncker¹, Rosella Mollicone, Jean-Jacques Candelier, Christelle Breton, Rafael Oriol

Affiliation

¹ Unité de Glycobiologie et Signalisation Cellulaire, INSERM U504, GDR CNRS 2590, Université de Paris Sud XI, 16 Ave Paul Vaillant-Couturier, 94807 Villejuif Cedex France.

PMID: 12966037
DOI: 10.1093/glycob/cwg113

Abstract

The presence of three conserved peptide motifs shared by alpha2-fucosyltransferases, alpha6-fucosyltransferases, the protein-O-fucosyltransferase family 1 (POFUT1) and a newly identified protein-O-fucosyltransferase family 2 (POFUT2), together with evidence that the present genes encoding for these enzymes have originated from a common ancestor by duplication and divergent evolution, suggests that they constitute a new superfamily of fucosyltransferases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Motifs
Amino Acid Sequence
Animals
Conserved Sequence
Fucosyltransferases / chemistry*
Fucosyltransferases / classification
Fucosyltransferases / genetics
Humans
Molecular Sequence Data
Phylogeny
Sequence Homology, Amino Acid

Substances

Fucosyltransferases

Associated data

GENBANK/AJ514425
GENBANK/AJ514872
GENBANK/AJ515151
GENBANK/AJ515152
GENBANK/AJ535754
GENBANK/AJ567917
GENBANK/AJ575591
GENBANK/AJ575656
GENBANK/AJ575657