Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases

T Yamaguchi; S Izuta; M Suzuki; S Yoshida; A Matsukage; M Saneyoshi

Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases

Nucleic Acids Symp Ser. 1992:(27):191-2.

Authors

T Yamaguchi¹, S Izuta, M Suzuki, S Yoshida, A Matsukage, M Saneyoshi

Affiliation

¹ Department of Biological Sciences, Nishi-Tokyo University, Yamanashi, Japan.

PMID: 1283906

Abstract

Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.

MeSH terms

Eukaryotic Cells / enzymology
HIV Reverse Transcriptase
Nucleic Acid Synthesis Inhibitors*
Reverse Transcriptase Inhibitors*
Styrenes / pharmacology*
Uridine Triphosphate / analogs & derivatives*
Uridine Triphosphate / pharmacology

Substances

Nucleic Acid Synthesis Inhibitors
Reverse Transcriptase Inhibitors
Styrenes
HIV Reverse Transcriptase
Uridine Triphosphate