The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor

Yan Sun; De-ming Gou; Hui Liu; Xiao Peng; Wen-xin Li

doi:10.1080/1521654031000110208

The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor

IUBMB Life. 2003 Mar;55(3):127-31. doi: 10.1080/1521654031000110208.

Authors

Yan Sun¹, De-ming Gou, Hui Liu, Xiao Peng, Wen-xin Li

Affiliation

¹ College of Life Sciences, Wuhan University, Wuhan 430072, P.R. China.

PMID: 12822888
DOI: 10.1080/1521654031000110208

Abstract

Nearly one-third of Krupple-type C2H2 zinc finger proteins have a krupple-associated box (KRAB) domain, which may act as a transcriptional repressor. ZNF268, which was novelty isolated from early human embryo, is a typical krupple-type C2H2 zinc finger protein with a conserved KRAB domain. In this report, the KRAB domain of ZNF268 is identified to localize in the nucleus and has transcriptional repressor activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
COS Cells
Consensus Sequence
Conserved Sequence
DNA-Binding Proteins / chemistry
DNA-Binding Proteins / metabolism*
Embryo, Mammalian
Humans
Molecular Sequence Data
Nuclear Proteins / chemistry
Nuclear Proteins / metabolism
Protein Structure, Tertiary
Recombinant Fusion Proteins / metabolism
Repressor Proteins / chemistry
Repressor Proteins / metabolism*
Sequence Homology, Amino Acid
Transcription Factors / chemistry
Transcription Factors / metabolism*
Transcription, Genetic
Zinc Fingers*

Substances

DNA-Binding Proteins
Nuclear Proteins
Recombinant Fusion Proteins
Repressor Proteins
Transcription Factors
ZNF268 protein, human