Abstract
We have cloned and sequenced the human KIT proto-oncogene, which contains 21 exons and spans more than 34 kb of DNA on chromosome segment 4q12. We also establish physical linkage between the KIT gene and the related PDGFRA gene. The organization of the KIT gene is virtually identical to that of the homologous FMS gene, located on chromosome 5. Together, these data suggest that the KIT and PDGFRA genes on chromosome 4 and the FMS and PDGFRB genes on chromosome 5 arose by duplication of a common ancestral gene, followed by duplication of a chromosome.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Genes, fms
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Genetic Linkage
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Humans
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Molecular Sequence Data
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Promoter Regions, Genetic
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Proto-Oncogene Mas
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins c-kit
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Proto-Oncogenes*
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RNA Splicing
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RNA, Messenger / analysis
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Receptors, Platelet-Derived Growth Factor / genetics
Substances
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MAS1 protein, human
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Proto-Oncogene Mas
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Proto-Oncogene Proteins
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RNA, Messenger
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Proto-Oncogene Proteins c-kit
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Receptors, Platelet-Derived Growth Factor