Abstract
The frequencies of nonselected mutations among adaptive Lac(+) revertants of Escherichia coli strains with and without the error-prone DNA polymerase IV (Pol IV) were compared. This frequency was more than sevenfold lower in the Pol IV-defective strain than in the wild-type strain. Thus, the mutations that occur during hypermutation are due to Pol IV.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adaptation, Physiological*
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Culture Media
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DNA Polymerase beta / metabolism*
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Escherichia coli / enzymology*
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Escherichia coli / genetics
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Escherichia coli / growth & development
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / metabolism
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Lactose / metabolism
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Mutation*
Substances
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Culture Media
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Escherichia coli Proteins
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DNA Polymerase beta
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Lactose