Abstract
The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adhesins, Bacterial / genetics
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Bacterial Adhesion
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Bacterial Proteins / genetics
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Biological Evolution*
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Carrier Proteins / genetics
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Carrier Proteins / metabolism
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Chromosomes, Bacterial / genetics
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Conjugation, Genetic
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Conserved Sequence
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DNA Transposable Elements
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Digestive System / microbiology
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Drug Resistance, Multiple, Bacterial
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Enterococcus faecalis / drug effects
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Enterococcus faecalis / genetics*
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Enterococcus faecalis / pathogenicity
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Enterococcus faecalis / physiology
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Gene Transfer, Horizontal
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Genome, Bacterial*
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Gram-Positive Bacterial Infections / microbiology
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Humans
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Interspersed Repetitive Sequences*
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Lysogeny
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Open Reading Frames
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Oxidative Stress
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Plasmids
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Sequence Analysis, DNA*
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Synteny
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Vancomycin Resistance / genetics*
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Virulence / genetics
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Virulence Factors / genetics
Substances
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Adhesins, Bacterial
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Bacterial Proteins
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Carrier Proteins
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DNA Transposable Elements
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Virulence Factors