Abstract
Semaphorins constitute one of the largest families of repulsive and attractive growth cone guidance proteins. They affect the growth cone's actin cytoskeleton through interactions with receptor complexes composed of ligand-binding, signal-transducing, and modulatory subunits. Our understanding of the intracellular signal transduction machinery linking semaphorins to actin dynamics is limited; however, recent advances provide a more comprehensive view of the molecular basis of neuronal semaphorin signaling.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Actin Cytoskeleton / genetics
-
Actin Cytoskeleton / metabolism
-
Animals
-
Cell Differentiation / genetics
-
Gene Expression Regulation, Developmental / genetics
-
Growth Cones / metabolism
-
Growth Cones / ultrastructure*
-
Humans
-
Nervous System / cytology
-
Nervous System / embryology*
-
Nervous System / metabolism
-
Neural Pathways / cytology
-
Neural Pathways / embryology*
-
Neural Pathways / metabolism
-
Semaphorins / genetics
-
Semaphorins / metabolism*
-
Signal Transduction / genetics*