Abstract
A family of membrane-associated proteins related to yeast Lag1p and mammalian TRAM has been identified. The family includes the protein product of CLN8, a gene mutated in progressive epilepsy with mental retardation. Mouse CLN8 is also mutated in the mnd/mnd mouse, a model for neuronal ceroid lipofuscinoses. The identification of these homologues has potential implications for our understanding of ceramide synthesis, lipid regulation and protein translocation in the endoplasmic reticulum.
MeSH terms
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Amino Acid Sequence
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Animals
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Fungal Proteins / genetics
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Fungal Proteins / metabolism*
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Humans
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Lipid Metabolism*
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / metabolism*
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Membrane Transport Proteins
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Mice
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Molecular Sequence Data
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Mutation
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Protein Structure, Tertiary
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Saccharomyces cerevisiae Proteins*
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Sequence Homology, Amino Acid
Substances
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CLN8 protein, human
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Cln8 protein, mouse
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Fungal Proteins
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LAG1 protein, S cerevisiae
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Membrane Glycoproteins
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Membrane Proteins
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Membrane Transport Proteins
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Saccharomyces cerevisiae Proteins
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TRAM1 protein, human
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translocating chain-associating membrane protein (TRAM)