Molecular pathogenesis of iron overload

D Trinder; C Fox; G Vautier; J K Olynyk

doi:10.1136/gut.51.2.290

Molecular pathogenesis of iron overload

Gut. 2002 Aug;51(2):290-5. doi: 10.1136/gut.51.2.290.

Authors

D Trinder¹, C Fox, G Vautier, J K Olynyk

Affiliation

¹ Department of Medicine and Western Australian Institute for Medical Research, University of Western Australia, Freemantle, Australia.

Abstract

Our current understanding of iron absorption under normal conditions is presented, together with an overview of the clinical disorders of iron overload and the molecular processes that contribute to increased iron deposition in iron overload. Recently, a number of new genes involved in iron metabolism have been identified which is allowing the molecular mechanisms of iron absorption to be elucidated.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Enterocytes / metabolism*
Gene Expression
Heme / metabolism
Hemochromatosis / metabolism
Humans
Intestinal Absorption / genetics*
Iron / metabolism*
Iron Overload / genetics*
Iron Overload / metabolism
Liver / metabolism
Liver Diseases / metabolism
Models, Biological
Receptors, Transferrin / metabolism

Substances

Receptors, Transferrin
Heme
Iron