Low expression of DNA polymerase beta in human testicular germ cell tumours--impact on foetal gonocytic origin theory

Radosława Nowak; Ewa A Grzybowska; Anna Wilczyńska; Roman Pykało; Janusz A Siedlecki

doi:10.1080/028418602753669580

Low expression of DNA polymerase beta in human testicular germ cell tumours--impact on foetal gonocytic origin theory

Acta Oncol. 2002;41(2):188-91. doi: 10.1080/028418602753669580.

Authors

Radosława Nowak¹, Ewa A Grzybowska, Anna Wilczyńska, Roman Pykało, Janusz A Siedlecki

Affiliation

¹ Department of Molecular Biology, The Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland. radka@coi.waw.pl

PMID: 12102165
DOI: 10.1080/028418602753669580

Abstract

Different models of pathogenesis of adult testicular germ cell tumours (TGCTs) are presented. Analysis of telomeric length and DNA polymerase beta expression suggests that seminoma and nonseminoma, two main histological types of TGCTs, derive independently from transformed foetal primordial cells.

MeSH terms

Blotting, Northern
DNA Polymerase beta / metabolism*
Embryonic and Fetal Development / genetics
Embryonic and Fetal Development / physiology*
Germinoma / enzymology*
Germinoma / pathology
Humans
Male
RNA, Messenger / metabolism
RNA, Neoplasm / metabolism
Spermatocytes / enzymology
Spermatocytes / pathology
Spermatogenesis
Telomere / metabolism
Testicular Neoplasms / enzymology*
Testicular Neoplasms / pathology
Tumor Suppressor Protein p53 / metabolism

Substances

RNA, Messenger
RNA, Neoplasm
Tumor Suppressor Protein p53
DNA Polymerase beta