The 3' 5' exonucleases

Nat Rev Mol Cell Biol. 2002 May;3(5):364-76. doi: 10.1038/nrm804.

Abstract

Over the past few years, several new 3' 5' exonucleases have been identified. In vitro studies of these enzymes have uncovered much about their potential functions in vivo, and certain organisms with a defect in 3' 5' exonucleases have an increased susceptibility to cancer, especially under conditions of stress. Here, we look at not only the newly discovered enzymes, but also at the roles of other 3' 5' exonucleases in the quality control of DNA synthesis, where they act as proofreading exonucleases for DNA polymerases during DNA replication, repair and recombination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • DNA Helicases / physiology
  • DNA Polymerase III / physiology
  • DNA Repair / physiology*
  • DNA Replication / physiology*
  • Exodeoxyribonuclease V
  • Exodeoxyribonucleases / chemistry
  • Exodeoxyribonucleases / physiology*
  • Humans
  • Molecular Sequence Data
  • Phosphoproteins*
  • Protein Structure, Tertiary
  • RecQ Helicases
  • Recombination, Genetic*
  • Sequence Alignment
  • Werner Syndrome Helicase

Substances

  • Phosphoproteins
  • DNA Polymerase III
  • Exodeoxyribonucleases
  • Exodeoxyribonuclease V
  • three prime repair exonuclease 1
  • DNA Helicases
  • RecQ Helicases
  • WRN protein, human
  • Werner Syndrome Helicase