Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system

Semin Immunol. 2001 Dec;13(6):339-45. doi: 10.1006/smim.2001.0330.

Abstract

Phagocytosis is a phylogenetically ancient process by which eukaryotic cells engulf insoluble substances whose size exceeds approximately 0.5 microm. The engulfment process requires the concerted action of several fundamental cellular pathways and is governed by multiple transmembrane signaling events. Here we focus on phagocytosis mediated by a well-studied class of phagocytic receptors that recognize the Fc portion of IgG (Fc(gamma)Rs ).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • ADP-Ribosylation Factor 6
  • ADP-Ribosylation Factors / physiology
  • Actins / metabolism
  • Animals
  • Cytoskeleton / physiology
  • Enzyme Precursors / physiology
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Isoenzymes / metabolism
  • Phagocytosis / physiology*
  • Phosphatidylinositol 3-Kinases
  • Phospholipase C gamma
  • Phosphorylation
  • Protein-Tyrosine Kinases / physiology
  • Receptors, IgG / physiology*
  • Signal Transduction*
  • Syk Kinase
  • Type C Phospholipases / metabolism
  • src-Family Kinases / physiology

Substances

  • ADP-Ribosylation Factor 6
  • Actins
  • Enzyme Precursors
  • Intracellular Signaling Peptides and Proteins
  • Isoenzymes
  • Receptors, IgG
  • Protein-Tyrosine Kinases
  • SYK protein, human
  • Syk Kinase
  • src-Family Kinases
  • Type C Phospholipases
  • Phospholipase C gamma
  • ADP-Ribosylation Factors