Error-prone DNA polymerases: novel structures and the benefits of infidelity

E C Friedberg; P L Fischhaber; C Kisker

doi:10.1016/s0092-8674(01)00509-8

Error-prone DNA polymerases: novel structures and the benefits of infidelity

Cell. 2001 Oct 5;107(1):9-12. doi: 10.1016/s0092-8674(01)00509-8.

Authors

E C Friedberg¹, P L Fischhaber, C Kisker

Affiliation

¹ Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. errol.friedberg@utsouthwestern.edu

PMID: 11595180
DOI: 10.1016/s0092-8674(01)00509-8

Abstract

Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.

Publication types

Comment
Review

MeSH terms

Amino Acid Sequence
Crystallography, X-Ray
DNA Damage
DNA Repair
DNA Replication
DNA-Directed DNA Polymerase / chemistry*
DNA-Directed DNA Polymerase / metabolism*
Humans
Models, Molecular
Molecular Sequence Data
Mutation
Protein Conformation
Protein Structure, Tertiary
Sequence Alignment

Substances

DNA-Directed DNA Polymerase