Abstract
The mechanistic basis for some examples of HIV-1 NRTI-resistance can be examined using altered incorporation of nucleoside analogs and surveying what is known about the more recently described mechanisms of chain-terminator removal. The complexity of these resistance mechanisms and the interplay with other factors that contribute to NRT1 resistance are only just beginning to be appreciated.
MeSH terms
-
Adenine / analogs & derivatives*
-
Adenine / pharmacology
-
Adenosine Triphosphate / metabolism
-
Anti-HIV Agents / pharmacology*
-
Drug Resistance, Microbial
-
HIV-1 / drug effects*
-
HIV-1 / enzymology
-
HIV-1 / genetics
-
Mutation
-
Organophosphonates*
-
Organophosphorus Compounds / pharmacology
-
RNA-Directed DNA Polymerase / chemistry
-
RNA-Directed DNA Polymerase / genetics
-
Reverse Transcriptase Inhibitors / chemistry
-
Reverse Transcriptase Inhibitors / pharmacology*
-
Stavudine / pharmacology
-
Tenofovir
-
Zidovudine / pharmacology
Substances
-
Anti-HIV Agents
-
Organophosphonates
-
Organophosphorus Compounds
-
Reverse Transcriptase Inhibitors
-
Zidovudine
-
Adenosine Triphosphate
-
Tenofovir
-
Stavudine
-
RNA-Directed DNA Polymerase
-
Adenine