Mechanisms of HIV-1 nucleoside reverse transcriptase inhibitor resistance: is it all figured out?

Curr Opin Investig Drugs. 2001 Mar;2(3):335-9.

Abstract

The mechanistic basis for some examples of HIV-1 NRTI-resistance can be examined using altered incorporation of nucleoside analogs and surveying what is known about the more recently described mechanisms of chain-terminator removal. The complexity of these resistance mechanisms and the interplay with other factors that contribute to NRT1 resistance are only just beginning to be appreciated.

Publication types

  • Review

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / pharmacology
  • Adenosine Triphosphate / metabolism
  • Anti-HIV Agents / pharmacology*
  • Drug Resistance, Microbial
  • HIV-1 / drug effects*
  • HIV-1 / enzymology
  • HIV-1 / genetics
  • Mutation
  • Organophosphonates*
  • Organophosphorus Compounds / pharmacology
  • RNA-Directed DNA Polymerase / chemistry
  • RNA-Directed DNA Polymerase / genetics
  • Reverse Transcriptase Inhibitors / chemistry
  • Reverse Transcriptase Inhibitors / pharmacology*
  • Stavudine / pharmacology
  • Tenofovir
  • Zidovudine / pharmacology

Substances

  • Anti-HIV Agents
  • Organophosphonates
  • Organophosphorus Compounds
  • Reverse Transcriptase Inhibitors
  • Zidovudine
  • Adenosine Triphosphate
  • Tenofovir
  • Stavudine
  • RNA-Directed DNA Polymerase
  • Adenine