Abstract
An antisense oligodeoxynucleotide against the human immunodeficiency virus type 1 (HIV-1) Rev response element, a ribozyme complementary to the HIV-1 5'-LTR, and the reverse transcriptase inhibitors 9-(2-phosphonylmethoxyethyl) adenine (PMEA) and (R)-9-(2-phosphonylmethoxypropyl)-adenine (PMPA) inhibited virus replication in monocyte-derived macrophages more effectively when delivered in pH-sensitive liposomes compared to the free drugs.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenine / administration & dosage*
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Adenine / analogs & derivatives*
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Adenine / pharmacokinetics
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Anti-HIV Agents / administration & dosage*
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Anti-HIV Agents / pharmacokinetics
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Genes, env / genetics
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HIV-1 / drug effects*
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HIV-1 / physiology
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Humans
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Hydrogen-Ion Concentration
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Liposomes
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Macrophages / metabolism
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Macrophages / virology*
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Oligonucleotides, Antisense / administration & dosage*
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Oligonucleotides, Antisense / genetics
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Organophosphonates*
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Organophosphorus Compounds / administration & dosage*
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Organophosphorus Compounds / pharmacokinetics
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RNA, Catalytic / administration & dosage*
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Tenofovir
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Thionucleotides / administration & dosage
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Virus Replication / drug effects*
Substances
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Anti-HIV Agents
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Liposomes
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Oligonucleotides, Antisense
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Organophosphonates
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Organophosphorus Compounds
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RNA, Catalytic
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Thionucleotides
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adefovir
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Tenofovir
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Adenine