Human puromycin-sensitive aminopeptidase: cloning of 3' UTR, evidence for a polymorphism at a.a. 140 and refined chromosomal localization to 17q21

Cytogenet Cell Genet. 2001;92(3-4):221-4. doi: 10.1159/000056907.

Abstract

Puromycin-sensitive aminopeptidase is a predominantly cytoplasmatic zinc-dependent exopeptidase. Its physiological function is not known to date. Here we report data on tissue distribution, a polymorphism within the coding region and the complete 3' UTR. The gene (NPEPPS alias PSA) was physically mapped to chromosome 17q21.2-->q21.32 using fluorescence in situ hybridization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Untranslated Regions / genetics*
  • Amino Acid Sequence
  • Aminopeptidases / genetics*
  • Base Sequence
  • Chromosome Banding
  • Chromosomes, Human, Pair 17 / genetics*
  • Cloning, Molecular
  • DNA, Complementary / genetics
  • Expressed Sequence Tags
  • Gene Expression Profiling
  • Gene Expression Regulation / drug effects
  • Humans
  • In Situ Hybridization, Fluorescence
  • Physical Chromosome Mapping
  • Polymorphism, Genetic / genetics*
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics
  • Sequence Alignment
  • Vitamin D / pharmacology

Substances

  • 3' Untranslated Regions
  • DNA, Complementary
  • RNA, Messenger
  • Vitamin D
  • Aminopeptidases
  • enkephalin degrading enzyme