Abstract
Identification of imprinted genes in the Prader-Willi/Angelman syndrome deletion region is complicated by the presence of large flanking repeats. While inactive copies of DEXI are located within the repeats, we have now localized the active DEXI gene to 15q11-->q13 outside the PWS/AS deletion and Dexi to mouse chromosome 16, suggesting complex evolution of this genomic region in both species.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angelman Syndrome / genetics*
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Animals
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Chromosomes, Human, Pair 15 / genetics*
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Dexamethasone / pharmacology
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Evolution, Molecular
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Expressed Sequence Tags
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Genomic Imprinting / genetics*
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Humans
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Mice
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Mice, Inbred C57BL
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Mice, Inbred Strains
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Molecular Sequence Data
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Multigene Family / genetics*
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Open Reading Frames / genetics
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Physical Chromosome Mapping*
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Prader-Willi Syndrome / genetics*
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RNA, Messenger / genetics
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Transcription, Genetic / drug effects
Substances
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RNA, Messenger
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Dexamethasone