Synthesis of sulfoquinovosylacylglycerols, inhibitors of eukaryotic DNA polymerase alpha and beta

S Hanashima; Y Mizushina; T Yamazaki; K Ohta; S Takahashi; H Sahara; K Sakaguchi; F Sugawar

doi:10.1016/s0968-0896(00)00252-2

Synthesis of sulfoquinovosylacylglycerols, inhibitors of eukaryotic DNA polymerase alpha and beta

Bioorg Med Chem. 2001 Feb;9(2):367-76. doi: 10.1016/s0968-0896(00)00252-2.

Authors

S Hanashima¹, Y Mizushina, T Yamazaki, K Ohta, S Takahashi, H Sahara, K Sakaguchi, F Sugawar

Affiliation

¹ Department of Applied Biological Science, Science University of Tokyo, Noda, Chiba, Japan.

PMID: 11249129
DOI: 10.1016/s0968-0896(00)00252-2

Abstract

Sulfoquinovosyldiacylglycerols (SQDGs) and sulfoquinovosylmonoacylglycerols (SQMGs), bearing diverse fatty acids, were synthesized from D-glucose, and were examined for enzymatic inhibitions of DNA polymerase alpha and beta. These results indicated that the carbon numbers of the fatty acids were highly related to the activities, at least in vitro, of eukaryotic DNA polymerase inhibition.

MeSH terms

Animals
Anti-HIV Agents / chemical synthesis
Anti-HIV Agents / pharmacology
Combinatorial Chemistry Techniques
DNA Polymerase I / antagonists & inhibitors*
DNA Polymerase beta / antagonists & inhibitors*
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / pharmacology
Eukaryotic Cells / enzymology
Glycolipids / chemical synthesis
Glycolipids / pharmacology*
Humans
Inhibitory Concentration 50
Structure-Activity Relationship

Substances

Anti-HIV Agents
Enzyme Inhibitors
Glycolipids
sulfoquinovosyl diglyceride
DNA Polymerase I
DNA Polymerase beta