Abstract
Screening a human small intestinal library with human serum yielded a clone which encoded a protein res4-22 the gene of which was highly homologous to a recently described gene located in the Huntington's disease locus. Autoantibodies against res4-22 (anti-res4-22), mainly of the immunoglobulin (Ig)A type, were detected in patients with neurological disorders at a higher frequency (18.4%) than in healthy blood donors (8.0%). In neurological patients with cerebral ischaemia anti-res4-22 was found significantly more often (47.4%) than in the total group of neurological patients. Anti-res4-22 positive sera showed significantly more frequently myelin staining in cerebellum and nerve sections than anti-res4-22 negative sera. Our findings demonstrate a new species of human autoantibodies against a newly described protein the function of which is still unknown.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Autoantibodies / blood
-
Autoantibodies / immunology*
-
Autoantigens / genetics
-
Autoantigens / immunology*
-
Autoimmune Diseases of the Nervous System / blood
-
Autoimmune Diseases of the Nervous System / genetics
-
Autoimmune Diseases of the Nervous System / immunology
-
Brain Ischemia / blood
-
Brain Ischemia / immunology
-
Cerebellum / immunology
-
Chromosomes, Human, Pair 4 / genetics*
-
Gene Library
-
Genes
-
Humans
-
Huntingtin Protein
-
Immunoglobulin A / immunology*
-
Intestinal Mucosa / chemistry
-
Intestine, Small / chemistry
-
Microscopy, Fluorescence
-
Muscle, Smooth / chemistry
-
Myelin Sheath / immunology
-
Nerve Tissue Proteins / genetics
-
Nerve Tissue Proteins / immunology*
-
Nervous System Diseases / blood
-
Nervous System Diseases / genetics
-
Nervous System Diseases / immunology*
-
Nuclear Proteins / genetics
-
Proteins
-
Schwann Cells / chemistry
-
Sequence Homology, Nucleic Acid
Substances
-
Autoantibodies
-
Autoantigens
-
FAM193A protein, human
-
HTT protein, human
-
Huntingtin Protein
-
Immunoglobulin A
-
Nerve Tissue Proteins
-
Nuclear Proteins
-
Proteins