Neurological disease-associated autoantibodies against an unknown protein encoded by a RES4-22 homologous gene

Scand J Immunol. 2001 Feb;53(2):204-8. doi: 10.1046/j.1365-3083.2001.00839.x.

Abstract

Screening a human small intestinal library with human serum yielded a clone which encoded a protein res4-22 the gene of which was highly homologous to a recently described gene located in the Huntington's disease locus. Autoantibodies against res4-22 (anti-res4-22), mainly of the immunoglobulin (Ig)A type, were detected in patients with neurological disorders at a higher frequency (18.4%) than in healthy blood donors (8.0%). In neurological patients with cerebral ischaemia anti-res4-22 was found significantly more often (47.4%) than in the total group of neurological patients. Anti-res4-22 positive sera showed significantly more frequently myelin staining in cerebellum and nerve sections than anti-res4-22 negative sera. Our findings demonstrate a new species of human autoantibodies against a newly described protein the function of which is still unknown.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantibodies / blood
  • Autoantibodies / immunology*
  • Autoantigens / genetics
  • Autoantigens / immunology*
  • Autoimmune Diseases of the Nervous System / blood
  • Autoimmune Diseases of the Nervous System / genetics
  • Autoimmune Diseases of the Nervous System / immunology
  • Brain Ischemia / blood
  • Brain Ischemia / immunology
  • Cerebellum / immunology
  • Chromosomes, Human, Pair 4 / genetics*
  • Gene Library
  • Genes
  • Humans
  • Huntingtin Protein
  • Immunoglobulin A / immunology*
  • Intestinal Mucosa / chemistry
  • Intestine, Small / chemistry
  • Microscopy, Fluorescence
  • Muscle, Smooth / chemistry
  • Myelin Sheath / immunology
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / immunology*
  • Nervous System Diseases / blood
  • Nervous System Diseases / genetics
  • Nervous System Diseases / immunology*
  • Nuclear Proteins / genetics
  • Proteins
  • Schwann Cells / chemistry
  • Sequence Homology, Nucleic Acid

Substances

  • Autoantibodies
  • Autoantigens
  • FAM193A protein, human
  • HTT protein, human
  • Huntingtin Protein
  • Immunoglobulin A
  • Nerve Tissue Proteins
  • Nuclear Proteins
  • Proteins