Gene diversity of chimpanzee ABO blood group genes elucidated from exon 7 sequences

Gene. 2000 Dec 23;259(1-2):75-9. doi: 10.1016/s0378-1119(00)00440-6.

Abstract

Human and non-human primate ABO blood group genes show relatively large numbers of nucleotide differences. In this study, we determined exon 7 sequences for 10 individuals of common chimpanzee and for four individuals of bonobo to estimate nucleotide diversities among them. Sequence data showed the existence of chimpanzee specific 9-base deletion in the beginning of the exon 7 coding region. From a phylogenetic network of exon 7 sequences of ABO blood group genes for human, common chimpanzee, bonobo and gorilla, effects of parallel substitutions and/or some kinds of convergent events are inferred in the chimpanzee lineage. We also estimated nucleotide diversities for common chimpanzee and bonobo ABO blood group genes, and these values were 0.4% and 0.2%, respectively. These values are higher than that of most human genes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ABO Blood-Group System / genetics*
  • Alleles
  • Animals
  • Base Sequence
  • DNA / chemistry
  • DNA / genetics
  • Exons / genetics*
  • Genetic Variation
  • Genotype
  • Glycosyltransferases / genetics*
  • Gorilla gorilla / genetics
  • Humans
  • Molecular Sequence Data
  • Pan paniscus / genetics
  • Pan troglodytes / genetics*
  • Phylogeny
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid

Substances

  • ABO Blood-Group System
  • DNA
  • Glycosyltransferases

Associated data

  • GENBANK/AB031368
  • GENBANK/AB031369
  • GENBANK/AB031370
  • GENBANK/AB031371
  • GENBANK/AB031372