Abstract
Two splicing variants of mouse hippostasin/TLSP (PRSS20) were identified and termed brain-type and prostate-type, respectively. Mouse hippostasin/TLSP showed 76.8% identity to the human homologue. Transient expression showed that both translational products were secreted into the conditioned medium. Mouse hippostasin/TLSP was expressed preferentially in the fetal brain and the prostate, but not in the neonatal brain. The brain expressed only brain-type hippostasin/TLSP, while the prostate expressed both types.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alternative Splicing / genetics*
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Amino Acid Sequence
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Animals
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Animals, Newborn
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Base Sequence
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Brain / embryology
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Brain / enzymology
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Brain / metabolism*
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COS Cells
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Cloning, Molecular
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Culture Media, Conditioned / metabolism
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DNA, Complementary / genetics
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Expressed Sequence Tags
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Humans
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Male
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Mice
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Molecular Sequence Data
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Organ Specificity
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Prostate / embryology
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Prostate / enzymology
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Prostate / metabolism*
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RNA, Messenger / analysis
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RNA, Messenger / genetics
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Sequence Alignment
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Sequence Homology
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Serine Endopeptidases / genetics*
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Serine Endopeptidases / metabolism
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Transfection
Substances
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Culture Media, Conditioned
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DNA, Complementary
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RNA, Messenger
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trypsin-like serine protease
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Serine Endopeptidases
Associated data
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GENBANK/AB016226
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GENBANK/AB016227