A new member of the acid-sensing ion channel family

Neuroreport. 2000 Jul 14;11(10):2217-22. doi: 10.1097/00001756-200007140-00031.

Abstract

Acid-sensing ion channels (ASICs) are members of the epithelial sodium channel (ENaC)-degenerin family of two-pass transmembrane segment protein subunits which form multimeric cation channels. Members of the ENaC-degenerin family are gated by stimuli as diverse as protons, peptides and mechanical distension. Here we describe a new member of the family, SPASIC or ASIC 4 (spinal cord ASIC) which is expressed throughout the central nervous system in an overlapping population of neurons that also express the ASIC subunit MDEG2. ASIC-4 which shows 44% identify with ASIC is developmentally regulated and expressed in a subset of sensory neurons as well as in the CNS. However, despite the strong homology with ASIC, the ASIC-4 transcript does not encode a proton gated cation channel.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acid Sensing Ion Channels
  • Amino Acid Sequence
  • Animals
  • COS Cells
  • Cell Line
  • Chlorocebus aethiops
  • Cloning, Molecular
  • Conserved Sequence
  • Degenerin Sodium Channels
  • Epithelial Sodium Channels
  • Ganglia, Spinal / metabolism
  • Gene Library
  • Ion Channels / chemistry
  • Ion Channels / genetics*
  • Ion Channels / physiology
  • Membrane Potentials / physiology
  • Membrane Proteins*
  • Molecular Sequence Data
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / genetics*
  • Nerve Tissue Proteins / physiology
  • Neurons / metabolism
  • Patch-Clamp Techniques
  • Protein Subunits
  • Rats
  • Recombinant Proteins / metabolism
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Sodium Channels / chemistry
  • Sodium Channels / genetics*
  • Sodium Channels / physiology
  • Spinal Cord / metabolism
  • Transcription, Genetic
  • Transfection

Substances

  • ASIC2 protein, human
  • ASIC3 protein, human
  • Acid Sensing Ion Channels
  • Asic2 protein, rat
  • Degenerin Sodium Channels
  • Epithelial Sodium Channels
  • Ion Channels
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Protein Subunits
  • Recombinant Proteins
  • Sodium Channels