Hemoglobin Moabit: alpha 86 (F7) Leu leads to Arg: a new unstable abnormal hemoglobin

Acta Haematol. 1979;61(3):121-4. doi: 10.1159/000207643.

Abstract

A new alpha chain abnormal hemoglobin variant was found in a Turkish patient with a mild Heinz body hemolytic anemia and splenomegaly. The substitution alpha 86 Leu leads to Arg, which is next to the heme binding proximal histidine, is responsible for a marked instability of the molecule. The oxygen affinity of the erythrocytes was found to be slightly decreased.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amino Acids / analysis
  • Anemia, Hemolytic, Congenital / blood*
  • Electrophoresis, Starch Gel
  • Erythrocytes / metabolism
  • Heinz Bodies
  • Heme / metabolism
  • Hemoglobins, Abnormal / analysis*
  • Humans
  • Oxygen / blood
  • Splenomegaly / blood*
  • Turkey / ethnology

Substances

  • Amino Acids
  • Hemoglobins, Abnormal
  • Heme
  • Oxygen