Genomic organization, proposed alternative splicing mechanisms, and RNA editing structure of GRIK1

A Barbon; S Barlati

doi:10.1159/000015558

Genomic organization, proposed alternative splicing mechanisms, and RNA editing structure of GRIK1

Cytogenet Cell Genet. 2000;88(3-4):236-9. doi: 10.1159/000015558.

Authors

A Barbon¹, S Barlati

Affiliation

¹ Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnologies, Brescia University Medical School, Italy.

PMID: 10828597
DOI: 10.1159/000015558

Abstract

In the present study, we report the genomic reconstruction of the glutamate receptor GluR5 gene (GRIK1, alias GLUR5; 402 kb) by the use of the data available in public databases. This analysis allowed characterization of the exon-intron boundaries, identification of the gene promoter region, presentation of the putative complete sequences of two GluR5 mRNA isoforms, and definition of the structure of GluR5 pre-mRNA surrounding the Q/R editing site.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alternative Splicing / genetics*
Base Sequence
Databases, Factual
Exons / genetics*
Expressed Sequence Tags
Humans
Introns / genetics*
Molecular Sequence Data
Promoter Regions, Genetic / genetics
Protein Isoforms / genetics
RNA Editing / genetics*
RNA Precursors / analysis
RNA Precursors / genetics
RNA, Messenger / analysis
RNA, Messenger / genetics
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate / genetics*
Repetitive Sequences, Nucleic Acid / genetics
Sequence Tagged Sites

Substances

Protein Isoforms
RNA Precursors
RNA, Messenger
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate