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Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK.
Zhao L, Hart S, Cheng J, Melenhorst JJ, Bierie B, Ernst M, Stewart C, Schaper F, Heinrich PC, Ullrich A, Robinson GW, Hennighausen L. Zhao L, et al. J Biol Chem. 2004 Oct 15;279(42):44093-100. doi: 10.1074/jbc.M313131200. Epub 2004 Jul 30. J Biol Chem. 2004. PMID: 15292206 Free article.
Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.
Yoshida K, Taga T, Saito M, Suematsu S, Kumanogoh A, Tanaka T, Fujiwara H, Hirata M, Yamagami T, Nakahata T, Hirabayashi T, Yoneda Y, Tanaka K, Wang WZ, Mori C, Shiota K, Yoshida N, Kishimoto T. Yoshida K, et al. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):407-11. doi: 10.1073/pnas.93.1.407. Proc Natl Acad Sci U S A. 1996. PMID: 8552649 Free PMC article.