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Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.
Immunity. 2000 Jan;12(1):95-105. doi: 10.1016/s1074-7613(00)80162-4.
Immunity. 2000.
PMID: 10661409
Free article.
Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation.
Ernst M, Inglese M, Waring P, Campbell IK, Bao S, Clay FJ, Alexander WS, Wicks IP, Tarlinton DM, Novak U, Heath JK, Dunn AR.
Ernst M, et al.
J Exp Med. 2001 Jul 16;194(2):189-203. doi: 10.1084/jem.194.2.189.
J Exp Med. 2001.
PMID: 11457894
Free PMC article.
Item in Clipboard
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice.
Tebbutt NC, Giraud AS, Inglese M, Jenkins B, Waring P, Clay FJ, Malki S, Alderman BM, Grail D, Hollande F, Heath JK, Ernst M.
Tebbutt NC, et al.
Nat Med. 2002 Oct;8(10):1089-97. doi: 10.1038/nm763. Epub 2002 Sep 9.
Nat Med. 2002.
PMID: 12219085
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Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK.
Zhao L, Hart S, Cheng J, Melenhorst JJ, Bierie B, Ernst M, Stewart C, Schaper F, Heinrich PC, Ullrich A, Robinson GW, Hennighausen L.
Zhao L, et al.
J Biol Chem. 2004 Oct 15;279(42):44093-100. doi: 10.1074/jbc.M313131200. Epub 2004 Jul 30.
J Biol Chem. 2004.
PMID: 15292206
Free article.
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Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes.
Walker EC, Truong K, McGregor NE, Poulton IJ, Isojima T, Gooi JH, Martin TJ, Sims NA.
Walker EC, et al.
Elife. 2020 May 27;9:e56666. doi: 10.7554/eLife.56666.
Elife. 2020.
PMID: 32458800
Free PMC article.
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Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.
Yoshida K, Taga T, Saito M, Suematsu S, Kumanogoh A, Tanaka T, Fujiwara H, Hirata M, Yamagami T, Nakahata T, Hirabayashi T, Yoneda Y, Tanaka K, Wang WZ, Mori C, Shiota K, Yoshida N, Kishimoto T.
Yoshida K, et al.
Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):407-11. doi: 10.1073/pnas.93.1.407.
Proc Natl Acad Sci U S A. 1996.
PMID: 8552649
Free PMC article.
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Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects.
Betz UA, Bloch W, van den Broek M, Yoshida K, Taga T, Kishimoto T, Addicks K, Rajewsky K, Müller W.
Betz UA, et al.
J Exp Med. 1998 Nov 16;188(10):1955-65. doi: 10.1084/jem.188.10.1955.
J Exp Med. 1998.
PMID: 9815272
Free PMC article.
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