Abstract
We report the precise mapping and characterization of ZIRTL (zinc-iron regulated transporter-like) gene, the first mammalian member of an extensive family of divalent metal ion transporters, comprising IRT1 and ZIP1, ZIP2, ZIP3, and ZIP4 in plants and ZRT1 and ZRT2 in yeast. The human gene maps at the telomeric end of the epidermal differentiation complex (EDC), within chromosomal band 1q21, while the mouse gene maps within the mouse EDC, on mouse chromosome 3, between S100A9 and S100A13. The structure of the human gene has been determined, and message was detected in most adult and fetal tissues including the epidermis. The mouse gene is developmentally regulated and found expressed in fetal and adult suprabasal epidermis, osteoblasts, small intestine, and salivary gland.
Copyright 1999 Academic Press.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Amino Acid Sequence
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Animals
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Base Sequence
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Blotting, Northern
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Carrier Proteins / biosynthesis
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Carrier Proteins / chemistry
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Carrier Proteins / genetics
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Carrier Proteins / isolation & purification*
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Cation Transport Proteins*
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Cell Differentiation / genetics
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Chromosomes, Human, Pair 1 / genetics
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Cloning, Molecular
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DNA, Complementary / chemistry
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DNA, Complementary / isolation & purification
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Epidermal Cells*
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Epidermis / metabolism*
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Exons
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Gene Expression Regulation, Developmental
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Humans
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In Situ Hybridization
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Introns
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Iron / metabolism
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Mice
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Molecular Sequence Data
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Multigene Family*
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Organ Specificity / genetics
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Sequence Homology, Amino Acid*
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Zinc / metabolism
Substances
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Carrier Proteins
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Cation Transport Proteins
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DNA, Complementary
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SLC39A1 protein, human
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Slc39a1 protein, mouse
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Iron
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Zinc
Associated data
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GENBANK/AJ243649
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GENBANK/AJ243650
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GENBANK/AJ243651