Abstract
We have cloned c-Irx2, a chick homologue of the Xiro2 and mIrx2 genes and a new member of the Iroquois family of homeodomain-containing transcription factors. Strikingly, c-Irx2 expression reveals an early subdivision of the neural plate at late primitive streak stages which later transiently resolves to a single stripe within the developing hindbrain corresponding to rhombomere 1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Cerebellum / embryology
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Cerebellum / metabolism
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Chick Embryo
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DNA, Complementary / metabolism
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Gene Expression*
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Homeodomain Proteins / genetics
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Homeodomain Proteins / metabolism*
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Mesencephalon / embryology
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Mesencephalon / metabolism*
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Molecular Sequence Data
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Rhombencephalon / embryology
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Rhombencephalon / metabolism*
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Sequence Homology, Amino Acid
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Time Factors
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Transcription Factors / genetics
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Transcription Factors / metabolism*
Substances
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DNA, Complementary
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Homeodomain Proteins
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Transcription Factors