10490823,16043515,17475214,18079394,19380743,19411071,19574958,19805105,20018188,20713702,21706016,22402981,23643389,23676467,24189400,25253337,25814554,26496610,28514442,30568254,32814053,34591612,34591642[uid] - Search Results

Year	Number of Results
1999	1
2005	1
2007	2
2009	5
2010	2
2011	1
2012	1
2013	3
2014	1
2015	2
2017	1
2018	1
2020	1
2021	2
2024	0

1

Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2.

Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA, Testa JR. Mitsuuchi Y, et al. Oncogene. 1999 Sep 2;18(35):4891-8. doi: 10.1038/sj.onc.1203080. Oncogene. 1999. PMID: 10490823

2

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex.

Luo J, Field SJ, Lee JY, Engelman JA, Cantley LC. Luo J, et al. J Cell Biol. 2005 Aug 1;170(3):455-64. doi: 10.1083/jcb.200503088. Epub 2005 Jul 25. J Cell Biol. 2005. PMID: 16043515 Free PMC article.

3

PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein.

Zhu Z, He X, Johnson C, Stoops J, Eaker AE, Stoffer DS, Bell A, Zarnegar R, DeFrances MC. Zhu Z, et al. Biochem Biophys Res Commun. 2007 Jun 22;358(1):66-72. doi: 10.1016/j.bbrc.2007.04.096. Epub 2007 Apr 24. Biochem Biophys Res Commun. 2007. PMID: 17475214 Free PMC article.

4

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.

Huang CH, Mandelker D, Schmidt-Kittler O, Samuels Y, Velculescu VE, Kinzler KW, Vogelstein B, Gabelli SB, Amzel LM. Huang CH, et al. Science. 2007 Dec 14;318(5857):1744-8. doi: 10.1126/science.1150799. Science. 2007. PMID: 18079394

5

Charting the molecular network of the drug target Bcr-Abl.

Brehme M, Hantschel O, Colinge J, Kaupe I, Planyavsky M, Köcher T, Mechtler K, Bennett KL, Superti-Furga G. Brehme M, et al. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7414-9. doi: 10.1073/pnas.0900653106. Epub 2009 Apr 20. Proc Natl Acad Sci U S A. 2009. PMID: 19380743 Free PMC article.

6

Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941.

Junttila TT, Akita RW, Parsons K, Fields C, Lewis Phillips GD, Friedman LS, Sampath D, Sliwkowski MX. Junttila TT, et al. Cancer Cell. 2009 May 5;15(5):429-40. doi: 10.1016/j.ccr.2009.03.020. Cancer Cell. 2009. PMID: 19411071 Free article.

7

Mal connects TLR2 to PI3Kinase activation and phagocyte polarization.

Santos-Sierra S, Deshmukh SD, Kalnitski J, Küenzi P, Wymann MP, Golenbock DT, Henneke P. Santos-Sierra S, et al. EMBO J. 2009 Jul 22;28(14):2018-27. doi: 10.1038/emboj.2009.158. Epub 2009 Jul 2. EMBO J. 2009. PMID: 19574958 Free PMC article.

8

A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane.

Mandelker D, Gabelli SB, Schmidt-Kittler O, Zhu J, Cheong I, Huang CH, Kinzler KW, Vogelstein B, Amzel LM. Mandelker D, et al. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):16996-7001. doi: 10.1073/pnas.0908444106. Epub 2009 Sep 23. Proc Natl Acad Sci U S A. 2009. PMID: 19805105 Free PMC article.

9

C-mip interacts with the p85 subunit of PI3 kinase and exerts a dual effect on ERK signaling via the recruitment of Dip1 and DAP kinase.

Kamal M, Pawlak A, BenMohamed F, Valanciuté A, Dahan K, Candelier M, Lang P, Guellaën G, Sahali D. Kamal M, et al. FEBS Lett. 2010 Feb 5;584(3):500-6. doi: 10.1016/j.febslet.2009.12.015. Epub 2009 Dec 16. FEBS Lett. 2010. PMID: 20018188 Free article.

10

Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha.

Sun M, Hillmann P, Hofmann BT, Hart JR, Vogt PK. Sun M, et al. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15547-52. doi: 10.1073/pnas.1009652107. Epub 2010 Aug 16. Proc Natl Acad Sci U S A. 2010. PMID: 20713702 Free PMC article.

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