Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance. Adult AIDS Clinical Trials Group CMV Laboratories

Antimicrob Agents Chemother. 1999 Jun;43(6):1500-2. doi: 10.1128/AAC.43.6.1500.

Abstract

The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1, 237 codons. Almost all variation occurred outside of conserved functional domains where resistance mutations have been identified.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antiviral Agents / pharmacology*
  • Codon
  • Cytomegalovirus / drug effects*
  • Cytomegalovirus / genetics
  • DNA-Directed DNA Polymerase / chemistry*
  • DNA-Directed DNA Polymerase / genetics
  • Drug Resistance, Microbial
  • Foscarnet / pharmacology
  • Ganciclovir / pharmacology
  • Genotype
  • Humans
  • Sequence Homology, Amino Acid

Substances

  • Antiviral Agents
  • Codon
  • Foscarnet
  • DNA-Directed DNA Polymerase
  • Ganciclovir