Synteny mapping of five human chromosome 7 genes on bovine chromosomes 4 and 21

Cytogenet Cell Genet. 1999;84(1-2):121-4. doi: 10.1159/000015236.

Abstract

Five genes on human chromosome 7 (HSA 7) were assigned to bovine chromosome 21 (BTA 21) and 4 (BTA 4) using a bovine-rodent somatic hybrid cell panel. These five genes were alpha-I subunit of adenylate cyclase-inhibiting G-protein (GNAI1), alpha/beta preprotachykinin (TAC1), reelin (RELN), c-AMP dependant protein kinase type II beta regulatory chain (PRKAR2B) and apolipoprotein A1 regulatory protein 1 (TFCOUP2). Four genes mapped to BTA 4 (GNAI1, TAC1, RELN, PRKAR2B) while one gene mapped to BTA 21 (TFCOUP2). This study confirms the synteny conservation between HSA 7 and BTA 4, finely maps the breakpoints of conserved synteny on HSA 7 and defines a new synteny conservation between HSA 7 and BTA 21.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenylyl Cyclase Inhibitors
  • Animals
  • Base Sequence
  • COUP Transcription Factors
  • Cattle / genetics*
  • Cell Adhesion Molecules, Neuronal / genetics
  • Chromosome Mapping
  • Chromosomes, Human, Pair 7 / genetics*
  • Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit
  • Cyclic AMP-Dependent Protein Kinase Type II
  • Cyclic AMP-Dependent Protein Kinases / genetics
  • DNA Primers / genetics
  • DNA-Binding Proteins / genetics
  • Extracellular Matrix Proteins / genetics
  • GTP-Binding Proteins / genetics
  • Humans
  • Hybrid Cells
  • Nerve Tissue Proteins
  • Polymerase Chain Reaction
  • Protein Precursors / genetics
  • Receptors, Steroid*
  • Reelin Protein
  • Serine Endopeptidases
  • Species Specificity
  • Tachykinins / genetics
  • Transcription Factors / genetics

Substances

  • Adenylyl Cyclase Inhibitors
  • COUP Transcription Factors
  • Cell Adhesion Molecules, Neuronal
  • Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit
  • DNA Primers
  • DNA-Binding Proteins
  • Extracellular Matrix Proteins
  • Nerve Tissue Proteins
  • PRKAR2B protein, human
  • Protein Precursors
  • Receptors, Steroid
  • Reelin Protein
  • Tachykinins
  • Transcription Factors
  • preprotachykinin
  • Cyclic AMP-Dependent Protein Kinase Type II
  • Cyclic AMP-Dependent Protein Kinases
  • RELN protein, human
  • Serine Endopeptidases
  • GTP-Binding Proteins