Abstract
Five genes on human chromosome 7 (HSA 7) were assigned to bovine chromosome 21 (BTA 21) and 4 (BTA 4) using a bovine-rodent somatic hybrid cell panel. These five genes were alpha-I subunit of adenylate cyclase-inhibiting G-protein (GNAI1), alpha/beta preprotachykinin (TAC1), reelin (RELN), c-AMP dependant protein kinase type II beta regulatory chain (PRKAR2B) and apolipoprotein A1 regulatory protein 1 (TFCOUP2). Four genes mapped to BTA 4 (GNAI1, TAC1, RELN, PRKAR2B) while one gene mapped to BTA 21 (TFCOUP2). This study confirms the synteny conservation between HSA 7 and BTA 4, finely maps the breakpoints of conserved synteny on HSA 7 and defines a new synteny conservation between HSA 7 and BTA 21.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adenylyl Cyclase Inhibitors
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Animals
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Base Sequence
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COUP Transcription Factors
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Cattle / genetics*
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Cell Adhesion Molecules, Neuronal / genetics
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Chromosome Mapping
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Chromosomes, Human, Pair 7 / genetics*
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Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit
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Cyclic AMP-Dependent Protein Kinase Type II
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Cyclic AMP-Dependent Protein Kinases / genetics
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DNA Primers / genetics
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DNA-Binding Proteins / genetics
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Extracellular Matrix Proteins / genetics
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GTP-Binding Proteins / genetics
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Humans
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Hybrid Cells
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Nerve Tissue Proteins
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Polymerase Chain Reaction
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Protein Precursors / genetics
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Receptors, Steroid*
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Reelin Protein
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Serine Endopeptidases
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Species Specificity
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Tachykinins / genetics
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Transcription Factors / genetics
Substances
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Adenylyl Cyclase Inhibitors
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COUP Transcription Factors
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Cell Adhesion Molecules, Neuronal
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Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit
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DNA Primers
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DNA-Binding Proteins
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Extracellular Matrix Proteins
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Nerve Tissue Proteins
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PRKAR2B protein, human
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Protein Precursors
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Receptors, Steroid
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Reelin Protein
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Tachykinins
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Transcription Factors
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preprotachykinin
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Cyclic AMP-Dependent Protein Kinase Type II
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Cyclic AMP-Dependent Protein Kinases
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RELN protein, human
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Serine Endopeptidases
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GTP-Binding Proteins