Angiopoietin-3, a novel member of the angiopoietin family

M Nishimura; T Miki; R Yashima; N Yokoi; H Yano; Y Sato; S Seino

doi:10.1016/s0014-5793(99)00381-6

Angiopoietin-3, a novel member of the angiopoietin family

FEBS Lett. 1999 Apr 9;448(2-3):254-6. doi: 10.1016/s0014-5793(99)00381-6.

Authors

M Nishimura¹, T Miki, R Yashima, N Yokoi, H Yano, Y Sato, S Seino

Affiliation

¹ The Program of the Chiba University School of Medicine, Chiba University Graduate School of Medicine, Japan.

PMID: 10218486
DOI: 10.1016/s0014-5793(99)00381-6

Abstract

A cDNA clone encoding angiopoietin-3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human angiopoietin-1 and human angiopoietin-2, respectively. Ang3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells (HUVECs). Ang3 mRNA expression in HUVECs was slightly decreased by vascular endothelial cell growth factor treatment, suggesting that the regulation of Ang3 mRNA expression is different from that of Ang2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Angiopoietin-Like Protein 1
Angiopoietin-like Proteins
Angiopoietins
Blotting, Northern
Chromosome Mapping
Chromosomes, Human, Pair 20
Cloning, Molecular
Databases, Factual
Dose-Response Relationship, Drug
Gene Expression Regulation
Humans
Intercellular Signaling Peptides and Proteins*
Molecular Sequence Data
Multigene Family
Physical Chromosome Mapping
Proteins / metabolism*
Sequence Homology, Amino Acid
Sequence Tagged Sites
Tissue Distribution

Substances

ANGPTL1 protein, human
Angiopoietin-Like Protein 1
Angiopoietin-like Proteins
Angiopoietins
Intercellular Signaling Peptides and Proteins
Proteins

Associated data

GENBANK/AC004064
GENBANK/AF074332