Nucleosides and nucleotides. 183. Synthesis of 4'alpha-branched thymidines as a new type of antiviral agent

I Sugimoto; S Shuto; S Mori; S Shigeta; A Matsuda

doi:10.1016/s0960-894x(99)00010-4

Nucleosides and nucleotides. 183. Synthesis of 4'alpha-branched thymidines as a new type of antiviral agent

Bioorg Med Chem Lett. 1999 Feb 8;9(3):385-8. doi: 10.1016/s0960-894x(99)00010-4.

Authors

I Sugimoto¹, S Shuto, S Mori, S Shigeta, A Matsuda

Affiliation

¹ Laboratory of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

PMID: 10091689
DOI: 10.1016/s0960-894x(99)00010-4

Abstract

A series of 4'alpha-branched thymidines was synthesized and evaluated as potential antiviral agents. 4'-Ethylthymidine (3), 4'-ethenylthymidine (5), and 4'-ethynylthymidine (6) exhibited potent anti-HSV-1 and anti-HIV-1 activities with no significant cytotoxicity.

MeSH terms

Antiviral Agents / chemical synthesis*
Antiviral Agents / pharmacology*
Cell Line
HIV-1 / drug effects
Herpesvirus 1, Human / drug effects
Microbial Sensitivity Tests
Thymidine / analogs & derivatives*
Thymidine / chemical synthesis
Thymidine / pharmacology

Substances

Antiviral Agents
Thymidine