Abstract
Through a large-scale sequencing of genomic DNA at 3p22-->p21.3, we have isolated two human genes (ORCTL3 alias OCTL1 and ORCTL4 alias OCTL2) encoding novel members of the family of organic-cation transporter molecules. The predicted proteins revealed the highest similarities to recently- isolated organic-cation transporter proteins, rat OCT-1r, rat NLT and mouse NKT. The transcripts of both genes were expressed ubiquitously in various human tissues, but some tissue-specific transcripts were also observed in kidney, testis, or skeletal muscle. The two genes are clustered within a 52-kb region of genomic DNA and ORCTL4 lies about 27 kb telomeric to ORCTL3 in the genomic DNA sequence in a tail-to-head orientation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Blotting, Northern
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Carrier Proteins / genetics*
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Chromosome Mapping
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Chromosomes, Human, Pair 3 / genetics
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Cloning, Molecular
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DNA / chemistry
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DNA / genetics
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DNA, Complementary / chemistry
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DNA, Complementary / genetics
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DNA, Complementary / isolation & purification
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Exons
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Genes / genetics*
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Humans
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In Situ Hybridization, Fluorescence
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Introns
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Molecular Sequence Data
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Organic Anion Transporters / genetics*
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RNA / genetics
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RNA / metabolism
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Sequence Alignment
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
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Tissue Distribution
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Transcription, Genetic
Substances
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Carrier Proteins
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DNA, Complementary
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Organic Anion Transporters
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SLC22A13 protein, human
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RNA
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DNA
Associated data
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GENBANK/AB010438
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GENBANK/AB011082
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GENBANK/AB026898
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GENBANK/AB026899