Abstract
The family of transcriptional inhibitors, IkappaBLs, are critical to the regulation of cytokine and chemokine production. We have identified the complete cDNA sequence of the mouse IkappabL gene. The predicted 381-amino-acid sequence showed evidence of two ankyrin repeats characteristic of Ikappab family proteins and 92% identity to the IkappaBL human homolog. Although human IkappaBL has been reported to be ubiquitously expressed, here we show that mouse IkappaBL is transcribed in a more tissue-specific manner.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adaptor Proteins, Signal Transducing
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Amino Acid Sequence
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Animals
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Base Sequence
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DNA, Complementary / genetics*
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DNA, Complementary / isolation & purification
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / genetics*
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Gene Expression
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Humans
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I-kappa B Proteins
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Mice
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Molecular Sequence Data
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Sequence Alignment
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Sequence Homology
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Transcription Factors / chemistry
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Transcription Factors / genetics*
Substances
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Adaptor Proteins, Signal Transducing
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DNA, Complementary
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DNA-Binding Proteins
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I-kappa B Proteins
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Nfkbil1 protein, mouse
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Transcription Factors