LOCUS NP_976084 449 aa linear PRI 16-NOV-2008
DEFINITION clusterin isoform 2 [Homo sapiens].
ACCESSION NP_976084
VERSION NP_976084.1 GI:42740907
DBSOURCE REFSEQ: accession NM_203339.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 449)
AUTHORS Partheen,K., Levan,K., Osterberg,L., Claesson,I., Fallenius,G.,
Sundfeldt,K. and Horvath,G.
TITLE Four potential biomarkers as prognostic factors in stage III serous
ovarian adenocarcinomas
JOURNAL Int. J. Cancer 123 (9), 2130-2137 (2008)
PUBMED 18709641
REMARK GeneRIF: the 4 biomarkers CLU, ITGB3, PRAME and CAPG may be used as
prognostic factors for patients with stage III serous ovarian
adenocarcinomas.
REFERENCE 2 (residues 1 to 449)
AUTHORS Ennis,S., Jomary,C., Mullins,R., Cree,A., Chen,X., Macleod,A.,
Jones,S., Collins,A., Stone,E. and Lotery,A.
TITLE Association between the SERPING1 gene and age-related macular
degeneration: a two-stage case-control study
JOURNAL Lancet (2008) In press
PUBMED 18842294
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Available-Online prior to print
REFERENCE 3 (residues 1 to 449)
AUTHORS Rauhala,H.E., Porkka,K.P., Saramaki,O.R., Tammela,T.L. and
Visakorpi,T.
TITLE Clusterin is epigenetically regulated in prostate cancer
JOURNAL Int. J. Cancer 123 (7), 1601-1609 (2008)
PUBMED 18649357
REMARK GeneRIF: Together with known function of clusterin, the data
suggest an epigenetic component in the regulation of clusterin in
prostate cancer
REFERENCE 4 (residues 1 to 449)
AUTHORS Poulakou,M.V., Paraskevas,K.I., Wilson,M.R., Iliopoulos,D.C.,
Tsigris,C., Mikhailidis,D.P. and Perrea,D.
TITLE Apolipoprotein J and leptin levels in patients with coronary heart
disease
JOURNAL In Vivo 22 (4), 537-542 (2008)
PUBMED 18712185
REMARK GeneRIF: ApoJ and leptin may have roles in coronary heart disease
REFERENCE 5 (residues 1 to 449)
AUTHORS Burdon,K.P., Sharma,S., Hewitt,A.W., McMellon,A.E., Wang,J.J.,
Mackey,D.A., Mitchell,P. and Craig,J.E.
TITLE Genetic analysis of the clusterin gene in pseudoexfoliation
syndrome
JOURNAL Mol. Vis. 14, 1727-1736 (2008)
PUBMED 18806885
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Online-Only
REFERENCE 6 (sites)
AUTHORS Kapron,J.T., Hilliard,G.M., Lakins,J.N., Tenniswood,M.P.,
West,K.A., Carr,S.A. and Crabb,J.W.
TITLE Identification and characterization of glycosylation sites in human
serum clusterin
JOURNAL Protein Sci. 6 (10), 2120-2133 (1997)
PUBMED 9336835
REFERENCE 7 (residues 1 to 449)
AUTHORS Choi-Miura,N.H., Takahashi,Y., Nakano,Y., Tobe,T. and Tomita,M.
TITLE Identification of the disulfide bonds in human plasma protein
SP-40,40 (apolipoprotein-J)
JOURNAL J. Biochem. 112 (4), 557-561 (1992)
PUBMED 1491011
REFERENCE 8 (residues 1 to 449)
AUTHORS Jenne,D.E. and Tschopp,J.
TITLE Clusterin: the intriguing guises of a widely expressed glycoprotein
JOURNAL Trends Biochem. Sci. 17 (4), 154-159 (1992)
PUBMED 1585460
REMARK Review article
REFERENCE 9 (residues 1 to 449)
AUTHORS Kirszbaum,L., Bozas,S.E. and Walker,I.D.
TITLE SP-40,40, a protein involved in the control of the complement
pathway, possesses a unique array of disulphide bridges
JOURNAL FEBS Lett. 297 (1-2), 70-76 (1992)
PUBMED 1551440
REFERENCE 10 (residues 1 to 449)
AUTHORS Dietzsch,E., Murphy,B.F., Kirszbaum,L., Walker,I.D. and Garson,O.M.
TITLE Regional localization of the gene for clusterin (SP-40,40; gene
symbol CLI) to human chromosome 8p12-->p21
JOURNAL Cytogenet. Cell Genet. 61 (3), 178-179 (1992)
PUBMED 1424805
REFERENCE 11 (residues 1 to 449)
AUTHORS James,R.W., Hochstrasser,A.C., Borghini,I., Martin,B., Pometta,D.
and Hochstrasser,D.
TITLE Characterization of a human high density lipoprotein-associated
protein, NA1/NA2. Identity with SP-40,40, an inhibitor of
complement-mediated cytolysis
JOURNAL Arterioscler. Thromb. 11 (3), 645-652 (1991)
PUBMED 1903064
REFERENCE 12 (sites)
AUTHORS de Silva,H.V., Harmony,J.A., Stuart,W.D., Gil,C.M. and Robbins,J.
TITLE Apolipoprotein J: structure and tissue distribution
JOURNAL Biochemistry 29 (22), 5380-5389 (1990)
PUBMED 1974459
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BX418836.2, BG819541.1, BX459023.2, BC019588.2, BQ181025.1,
BM723283.1 and BQ181739.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..449
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="8"
/map="8p21-p12"
Protein 1..449
/product="clusterin isoform 2"
/note="complement-associated protein SP-40;
aging-associated protein 4; clusterin (complement lysis
inhibitor, SP-40,40, sulfated glycoprotein 2,
testosterone-repressed prostate message 2, apolipoprotein
J)"
/calculated_mol_wt=52364
Site 86
/site_type="glycosylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[6]
Site 103
/site_type="glycosylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[6]
Site 145
/site_type="glycosylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[6]
Site 291
/site_type="glycosylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[6]
Site 354
/site_type="glycosylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[6]
Site 374
/site_type="glycosylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[6]
CDS 1..449
/gene="CLU"
/gene_synonym="CLI"
/gene_synonym="AAG4"
/gene_synonym="APOJ"
/gene_synonym="KUB1"
/gene_synonym="SGP2"
/gene_synonym="SGP-2"
/gene_synonym="SP-40"
/gene_synonym="TRPM2"
/gene_synonym="TRPM-2"
/gene_synonym="MGC24903"
/coded_by="NM_203339.1:306..1655"
/note="isoform 2 is encoded by transcript variant 2"
/db_xref="GeneID:1191"
/db_xref="HGNC:2095"
/db_xref="HPRD:01706"
/db_xref="MIM:185430"
ORIGIN
1 mmktlllfvg llltwesgqv lgdqtvsdne lqemsnqgsk yvnkeiqnav ngvkqiktli
61 ektneerktl lsnleeakkk kedalnetre setklkelpg vcnetmmalw eeckpclkqt
121 cmkfyarvcr sgsglvgrql eeflnqsspf yfwmngdrid sllendrqqt hmldvmqdhf
181 srassiidel fqdrfftrep qdtyhylpfs lphrrphfff pksrivrslm pfspyeplnf
241 hamfqpflem iheaqqamdi hfhspafqhp ptefiregdd drtvcreirh nstgclrmkd
301 qcdkcreils vdcstnnpsq aklrreldes lqvaerltrk ynellksyqw kmlntsslle
361 qlneqfnwvs rlanltqged qyylrvttva shtsdsdvps gvtevvvklf dsdpitvtvp
421 vevsrknpkf metvaekalq eyrkkhree
//