LOCUS NP_940807 419 aa linear ROD 24-OCT-2008
DEFINITION creatine kinase, mitochondrial 2 [Mus musculus].
ACCESSION NP_940807 XP_127443
VERSION NP_940807.1 GI:38259206
DBSOURCE REFSEQ: accession NM_198415.2
KEYWORDS .
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Sciurognathi; Muroidea; Muridae; Murinae; Mus.
REFERENCE 1 (residues 1 to 419)
AUTHORS Davie,J.K., Cho,J.H., Meadows,E., Flynn,J.M., Knapp,J.R. and
Klein,W.H.
TITLE Target gene selectivity of the myogenic basic helix-loop-helix
transcription factor myogenin in embryonic muscle
JOURNAL Dev. Biol. 311 (2), 650-664 (2007)
PUBMED 17904117
REFERENCE 2 (residues 1 to 419)
AUTHORS Yang,X.Y., Yang,T.T., Schubert,W., Factor,S.M. and Chow,C.W.
TITLE Dosage-dependent transcriptional regulation by the calcineurin/NFAT
signaling in developing myocardium transition
JOURNAL Dev. Biol. 303 (2), 825-837 (2007)
PUBMED 17198697
REFERENCE 3 (residues 1 to 419)
AUTHORS Novotova,M., Pavlovicova,M., Veksler,V.I., Ventura-Clapier,R. and
Zahradnik,I.
TITLE Ultrastructural remodeling of fast skeletal muscle fibers induced
by invalidation of creatine kinase
JOURNAL Am. J. Physiol., Cell Physiol. 291 (6), C1279-C1285 (2006)
PUBMED 16855221
REFERENCE 4 (residues 1 to 419)
AUTHORS Nahrendorf,M., Streif,J.U., Hiller,K.H., Hu,K., Nordbeck,P.,
Ritter,O., Sosnovik,D., Bauer,L., Neubauer,S., Jakob,P.M., Ertl,G.,
Spindler,M. and Bauer,W.R.
TITLE Multimodal functional cardiac MRI in creatine kinase-deficient mice
reveals subtle abnormalities in myocardial perfusion and mechanics
JOURNAL Am. J. Physiol. Heart Circ. Physiol. 290 (6), H2516-H2521 (2006)
PUBMED 16415075
REFERENCE 5 (residues 1 to 419)
AUTHORS Nahrendorf,M., Spindler,M., Hu,K., Bauer,L., Ritter,O.,
Nordbeck,P., Quaschning,T., Hiller,K.H., Wallis,J., Ertl,G.,
Bauer,W.R. and Neubauer,S.
TITLE Creatine kinase knockout mice show left ventricular hypertrophy and
dilatation, but unaltered remodeling post-myocardial infarction
JOURNAL Cardiovasc. Res. 65 (2), 419-427 (2005)
PUBMED 15639481
REFERENCE 6 (residues 1 to 419)
AUTHORS in 't Zandt,H.J., Oerlemans,F., Wieringa,B. and Heerschap,A.
TITLE Effects of ischemia on skeletal muscle energy metabolism in mice
lacking creatine kinase monitored by in vivo 31P nuclear magnetic
resonance spectroscopy
JOURNAL NMR Biomed 12 (6), 327-334 (1999)
PUBMED 10516614
REFERENCE 7 (residues 1 to 419)
AUTHORS Saupe,K.W., Spindler,M., Tian,R. and Ingwall,J.S.
TITLE Impaired cardiac energetics in mice lacking muscle-specific
isoenzymes of creatine kinase
JOURNAL Circ. Res. 82 (8), 898-907 (1998)
PUBMED 9576109
REFERENCE 8 (residues 1 to 419)
AUTHORS Boehm,E., Veksler,V., Mateo,P., Lenoble,C., Wieringa,B. and
Ventura-Clapier,R.
TITLE Maintained coupling of oxidative phosphorylation to creatine kinase
activity in sarcomeric mitochondrial creatine kinase-deficient mice
JOURNAL J. Mol. Cell. Cardiol. 30 (5), 901-912 (1998)
PUBMED 9618231
REFERENCE 9 (residues 1 to 419)
AUTHORS Steeghs,K., Benders,A., Oerlemans,F., de Haan,A., Heerschap,A.,
Ruitenbeek,W., Jost,C., van Deursen,J., Perryman,B., Pette,D.,
Bruckwilder,M., Koudijs,J., Jap,P., Veerkamp,J. and Wieringa,B.
TITLE Altered Ca2+ responses in muscles with combined mitochondrial and
cytosolic creatine kinase deficiencies
JOURNAL Cell 89 (1), 93-103 (1997)
PUBMED 9094718
REFERENCE 10 (residues 1 to 419)
AUTHORS Steeghs,K., Heerschap,A., de Haan,A., Ruitenbeek,W., Oerlemans,F.,
van Deursen,J., Perryman,B., Pette,D., Bruckwilder,M., Koudijs,J.,
Jap,P. and Wieringa,B.
TITLE Use of gene targeting for compromising energy homeostasis in
neuro-muscular tissues: the role of sarcomeric mitochondrial
creatine kinase
JOURNAL J. Neurosci. Methods 71 (1), 29-41 (1997)
PUBMED 9125373
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC061221.1.
On Dec 17, 2003 this sequence version replaced gi:20908987.
Sequence Note: removed 1 base from the 3' end that did not align to
the reference genome assembly.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..419
/organism="Mus musculus"
/db_xref="taxon:10090"
/chromosome="13"
Protein 1..419
/product="creatine kinase, mitochondrial 2"
/EC_number="2.7.3.2"
/calculated_mol_wt=47342
CDS 1..419
/gene="Ckmt2"
/gene_synonym="ScCKmit"
/gene_synonym="2300008A19Rik"
/coded_by="NM_198415.2:85..1344"
/db_xref="CCDS:CCDS26679.1"
/db_xref="GeneID:76722"
/db_xref="MGI:1923972"
ORIGIN
1 masafskllt grnasllftt lgtsalttgy llnrqkvsad areqhklfpp sadypdlrkh
61 nncmaecltp tiyaklrnkm tpsgytldqc iqtgvdnpgh pfiktvgmva gdeesyevfa
121 dlfdpviklr hngydprvmk hptdldaski thgqfderyv lssrvrtgrs irglslppac
181 sraerreven vaitaleglk gdlagryykl semteqdqqr liddhflfdk pvsplltcag
241 mardwpdarg iwhnydktfl iwineedhtr vismekggnm krvferfcrg lkeverliqe
301 rgwefmwner lgyiltcpsn lgtglragvh vripklskdp rfskilenlr lqkrgtggvd
361 taavadvydi snidrigrse velvqividg vnylvdcekk lergqdikvp pplpqfgrk
//