LOCUS NP_892022 1086 aa linear PRI 22-OCT-2008
DEFINITION nicotinamide nucleotide transhydrogenase [Homo sapiens].
ACCESSION NP_892022
VERSION NP_892022.2 GI:122939153
DBSOURCE REFSEQ: accession NM_182977.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 1086)
AUTHORS Jackson,J.B.
TITLE Proton translocation by transhydrogenase
JOURNAL FEBS Lett. 545 (1), 18-24 (2003)
PUBMED 12788487
REMARK Review article
REFERENCE 2 (residues 1 to 1086)
AUTHORS Taylor,S.W., Fahy,E., Zhang,B., Glenn,G.M., Warnock,D.E., Wiley,S.,
Murphy,A.N., Gaucher,S.P., Capaldi,R.A., Gibson,B.W. and Ghosh,S.S.
TITLE Characterization of the human heart mitochondrial proteome
JOURNAL Nat. Biotechnol. 21 (3), 281-286 (2003)
PUBMED 12592411
REFERENCE 3 (residues 1 to 1086)
AUTHORS Arkblad,E.L., Egorov,M., Shakhparonov,M., Romanova,L., Polzikov,M.
and Rydstrom,J.
TITLE Expression of proton-pumping nicotinamide nucleotide
transhydrogenase in mouse, human brain and C elegans
JOURNAL Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 133 (1), 13-21
(2002)
PUBMED 12223207
REMARK GeneRIF: the expression of the transhydrogenase gene in subsections
of the human brain showed a distribution that apparently varied as
a function of neuronal density
REFERENCE 4 (residues 1 to 1086)
AUTHORS Venter,J.C., Adams,M.D., Myers,E.W., Li,P.W., Mural,R.J.,
Sutton,G.G., Smith,H.O., Yandell,M., Evans,C.A., Holt,R.A.,
Gocayne,J.D., Amanatides,P., Ballew,R.M., Huson,D.H., Wortman,J.R.,
Zhang,Q., Kodira,C.D., Zheng,X.H., Chen,L., Skupski,M.,
Subramanian,G., Thomas,P.D., Zhang,J., Gabor Miklos,G.L.,
Nelson,C., Broder,S., Clark,A.G., Nadeau,J., McKusick,V.A.,
Zinder,N., Levine,A.J., Roberts,R.J., Simon,M., Slayman,C.,
Hunkapiller,M., Bolanos,R., Delcher,A., Dew,I., Fasulo,D.,
Flanigan,M., Florea,L., Halpern,A., Hannenhalli,S., Kravitz,S.,
Levy,S., Mobarry,C., Reinert,K., Remington,K., Abu-Threideh,J.,
Beasley,E., Biddick,K., Bonazzi,V., Brandon,R., Cargill,M.,
Chandramouliswaran,I., Charlab,R., Chaturvedi,K., Deng,Z., Di
Francesco,V., Dunn,P., Eilbeck,K., Evangelista,C., Gabrielian,A.E.,
Gan,W., Ge,W., Gong,F., Gu,Z., Guan,P., Heiman,T.J., Higgins,M.E.,
Ji,R.R., Ke,Z., Ketchum,K.A., Lai,Z., Lei,Y., Li,Z., Li,J.,
Liang,Y., Lin,X., Lu,F., Merkulov,G.V., Milshina,N., Moore,H.M.,
Naik,A.K., Narayan,V.A., Neelam,B., Nusskern,D., Rusch,D.B.,
Salzberg,S., Shao,W., Shue,B., Sun,J., Wang,Z., Wang,A., Wang,X.,
Wang,J., Wei,M., Wides,R., Xiao,C., Yan,C., Yao,A., Ye,J., Zhan,M.,
Zhang,W., Zhang,H., Zhao,Q., Zheng,L., Zhong,F., Zhong,W., Zhu,S.,
Zhao,S., Gilbert,D., Baumhueter,S., Spier,G., Carter,C.,
Cravchik,A., Woodage,T., Ali,F., An,H., Awe,A., Baldwin,D.,
Baden,H., Barnstead,M., Barrow,I., Beeson,K., Busam,D., Carver,A.,
Center,A., Cheng,M.L., Curry,L., Danaher,S., Davenport,L.,
Desilets,R., Dietz,S., Dodson,K., Doup,L., Ferriera,S., Garg,N.,
Gluecksmann,A., Hart,B., Haynes,J., Haynes,C., Heiner,C.,
Hladun,S., Hostin,D., Houck,J., Howland,T., Ibegwam,C., Johnson,J.,
Kalush,F., Kline,L., Koduru,S., Love,A., Mann,F., May,D.,
McCawley,S., McIntosh,T., McMullen,I., Moy,M., Moy,L., Murphy,B.,
Nelson,K., Pfannkoch,C., Pratts,E., Puri,V., Qureshi,H.,
Reardon,M., Rodriguez,R., Rogers,Y.H., Romblad,D., Ruhfel,B.,
Scott,R., Sitter,C., Smallwood,M., Stewart,E., Strong,R., Suh,E.,
Thomas,R., Tint,N.N., Tse,S., Vech,C., Wang,G., Wetter,J.,
Williams,S., Williams,M., Windsor,S., Winn-Deen,E., Wolfe,K.,
Zaveri,J., Zaveri,K., Abril,J.F., Guigo,R., Campbell,M.J.,
Sjolander,K.V., Karlak,B., Kejariwal,A., Mi,H., Lazareva,B.,
Hatton,T., Narechania,A., Diemer,K., Muruganujan,A., Guo,N.,
Sato,S., Bafna,V., Istrail,S., Lippert,R., Schwartz,R., Walenz,B.,
Yooseph,S., Allen,D., Basu,A., Baxendale,J., Blick,L., Caminha,M.,
Carnes-Stine,J., Caulk,P., Chiang,Y.H., Coyne,M., Dahlke,C.,
Mays,A., Dombroski,M., Donnelly,M., Ely,D., Esparham,S., Fosler,C.,
Gire,H., Glanowski,S., Glasser,K., Glodek,A., Gorokhov,M.,
Graham,K., Gropman,B., Harris,M., Heil,J., Henderson,S., Hoover,J.,
Jennings,D., Jordan,C., Jordan,J., Kasha,J., Kagan,L., Kraft,C.,
Levitsky,A., Lewis,M., Liu,X., Lopez,J., Ma,D., Majoros,W.,
McDaniel,J., Murphy,S., Newman,M., Nguyen,T., Nguyen,N., Nodell,M.,
Pan,S., Peck,J., Peterson,M., Rowe,W., Sanders,R., Scott,J.,
Simpson,M., Smith,T., Sprague,A., Stockwell,T., Turner,R.,
Venter,E., Wang,M., Wen,M., Wu,D., Wu,M., Xia,A., Zandieh,A. and
Zhu,X.
TITLE The sequence of the human genome
JOURNAL Science 291 (5507), 1304-1351 (2001)
PUBMED 11181995
REMARK Erratum:[Science 2001 Jun 5;292(5523):1838]
REFERENCE 5 (residues 1 to 1086)
AUTHORS Peake,S.J., Jackson,J.B. and White,S.A.
TITLE The NADP(H)-binding component (dIII) of human heart
transhydrogenase: crystallization and preliminary crystallographic
analysis
JOURNAL Acta Crystallogr. D Biol. Crystallogr. 56 (PT 4), 489-491 (2000)
PUBMED 10739929
REFERENCE 6 (residues 1 to 1086)
AUTHORS White,S.A., Peake,S.J., McSweeney,S., Leonard,G., Cotton,N.P. and
Jackson,J.B.
TITLE The high-resolution structure of the NADP(H)-binding component
(dIII) of proton-translocating transhydrogenase from human heart
mitochondria
JOURNAL Structure 8 (1), 1-12 (2000)
PUBMED 10673423
REFERENCE 7 (residues 1 to 1086)
AUTHORS Arkblad,E.L., Helou,K., Levan,G. and Rydstrom,J.
TITLE Mapping of the rat and mouse nicotinamide nucleotide
transhydrogenase gene
JOURNAL Mamm. Genome 8 (9), 703 (1997)
PUBMED 9271681
REFERENCE 8 (residues 1 to 1086)
AUTHORS Zieger,B. and Ware,J.
TITLE Cloning and deduced amino acid sequence of human nicotinamide
nucleotide transhydrogenase
JOURNAL DNA Seq. 7 (6), 369-373 (1997)
PUBMED 9524818
REFERENCE 9 (residues 1 to 1086)
AUTHORS Forsmark-Andree,P., Persson,B., Radi,R., Dallner,G. and Ernster,L.
TITLE Oxidative modification of nicotinamide nucleotide transhydrogenase
in submitochondrial particles: effect of endogenous ubiquinol
JOURNAL Arch. Biochem. Biophys. 336 (1), 113-120 (1996)
PUBMED 8951041
REFERENCE 10 (residues 1 to 1086)
AUTHORS Arkblad,E.L., Betsholtz,C. and Rydstrom,J.
TITLE The cDNA sequence of proton-pumping nicotinamide nucleotide
transhydrogenase from man and mouse
JOURNAL Biochim. Biophys. Acta 1273 (3), 203-205 (1996)
PUBMED 8616157
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BU429380.1, BC110543.1,
AC010435.6 and AW771969.1.
On Jan 18, 2007 this sequence version replaced gi:33695086.
Summary: This gene encodes an integral protein of the inner
mitochondrial membrane. The enzyme couples hydride transfer between
NAD(H) and NADP(+) to proton translocation across the inner
mitochondrial membrane. Under most physiological conditions, the
enzyme uses energy from the mitochondrial proton gradient to
produce high concentrations of NADPH. The resulting NADPH is used
for biosynthesis and in free radical detoxification. Two
alternatively spliced variants, encoding the same protein, have
been found for this gene. [provided by RefSeq].
Transcript Variant: This variant (2) differs in the 5' UTR compared
to variant 1.
FEATURES Location/Qualifiers
source 1..1086
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="5"
/map="5p13.1-cen"
Protein 1..1086
/product="nicotinamide nucleotide transhydrogenase"
/EC_number="1.6.1.2"
/note="NAD(P) transhydrogenase; pyridine nucleotide
transhydrogenase"
/calculated_mol_wt=113765
CDS 1..1086
/gene="NNT"
/gene_synonym="MGC126502"
/gene_synonym="MGC126503"
/coded_by="NM_182977.2:222..3482"
/db_xref="CCDS:CCDS3949.1"
/db_xref="GeneID:23530"
/db_xref="HGNC:7863"
/db_xref="MIM:607878"
ORIGIN
1 manllktvvt gcscpllsnl gsckglrvkk dflrtfythq elwckapvkp gipykqltvg
61 vpkeifqnek rvalspagvq nlvkqgfnvv vesgageask fsddhyrvag aqiqgakevl
121 asdlvvkvra pmvnptlgvh eadllktsgt lisfiypaqn pellnklsqr kttvlamdqv
181 prvtiaqgyd alssmaniag ykavvlaanh fgrfftgqit aagkvppaki livgggvagl
241 asagaaksmg aivrgfdtra aaleqfkslg aeplevdlke sgegqggyak emskefieae
301 mklfaqqcke vdilistali pgkkapvlfn kemiesmkeg svvvdlaaea ggnfettkpg
361 elyihkgith igytdlpsrm atqastlysn nitkllkais pdkdnfyfdv kddfdfgtmg
421 hvirgtvvmk dgkvifpapt pknipqgapv kqktvaelea ekaatitpfr ktmstasayt
481 agltgilglg iaapnlafsq mvttfglagi vgyhtvwgvt palhsplmsv tnaisgltav
541 gglalmgghl ypsttsqgla alaafissvn iaggflvtqr mldmfkrptd ppeynylyll
601 pagtfvggyl aalysgynie qimylgsglc cvgalaglst qgtarlgnal gmigvaggla
661 atlgvlkpgp ellaqmsgam alggtiglti akriqisdlp qlvaafhslv glaavltcia
721 eyiieyphfa tdaaanltki vaylgtyigg vtfsgsliay gklqgllksa plllpgrhll
781 nagllaasvg giipfmvdps fttgitclgs vsalsavmgv tltaaiggad mpvvitvlns
841 ysgwalcaeg fllnnnllti vgaligssga ilsyimcvam nrslanvilg gygttstagg
901 kpmeisgtht einldnaidm ireansiiit pgyglcaaka qypiadlvkm lteqgkkvrf
961 gihpvagrmp gqlnvllaea gvpydivlem deinhdfpdt dlvlvigand tvnsaaqedp
1021 nsiiagmpvl evwkskqviv mkrslgvgya avdnpifykp ntamllgdak ktcdalqakv
1081 resyqk
//