LOCUS       NP_874360                221 aa            linear   PRI 22-OCT-2008
DEFINITION  glutathione peroxidase 6 [Homo sapiens].
ACCESSION   NP_874360
VERSION     NP_874360.1  GI:33186887
DBSOURCE    REFSEQ: accession NM_182701.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 221)
  AUTHORS   Kryukov,G.V., Castellano,S., Novoselov,S.V., Lobanov,A.V.,
            Zehtab,O., Guigo,R. and Gladyshev,V.N.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
REFERENCE   2  (residues 1 to 221)
  AUTHORS   Richard,M.J., Guiraud,P., Didier,C., Seve,M., Flores,S.C. and
            Favier,A.
  TITLE     Human immunodeficiency virus type 1 Tat protein impairs
            selenoglutathione peroxidase expression and activity by a mechanism
            independent of cellular selenium uptake: consequences on cellular
            resistance to UV-A radiation
  JOURNAL   Arch. Biochem. Biophys. 386 (2), 213-220 (2001)
   PUBMED   11368344
REFERENCE   3  (residues 1 to 221)
  AUTHORS   Choi,J., Liu,R.M., Kundu,R.K., Sangiorgi,F., Wu,W., Maxson,R. and
            Forman,H.J.
  TITLE     Molecular mechanism of decreased glutathione content in human
            immunodeficiency virus type 1 Tat-transgenic mice
  JOURNAL   J. Biol. Chem. 275 (5), 3693-3698 (2000)
   PUBMED   10652368
REFERENCE   4  (residues 1 to 221)
  AUTHORS   Opalenik,S.R., Ding,Q., Mallery,S.R. and Thompson,J.A.
  TITLE     Glutathione depletion associated with the HIV-1 TAT protein
            mediates the extracellular appearance of acidic fibroblast growth
            factor
  JOURNAL   Arch. Biochem. Biophys. 351 (1), 17-26 (1998)
   PUBMED   9501919
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY324826.1.
            
            Summary: This gene product belongs to the glutathione peroxidase
            family, which functions in the detoxification of hydrogen peroxide.
            It contains a selenocysteine (Sec) residue at its active site. The
            selenocysteine is encoded by the UGA codon, which normally signals
            translation termination. The 3' UTR of Sec-containing genes have a
            common stem-loop structure, the sec insertion sequence (SECIS),
            which is necessary for the recognition of UGA as a Sec codon rather
            than as a stop signal. Expression of this gene is restricted to
            embryos and adult olfactory epithelium. [provided by RefSeq].
FEATURES             Location/Qualifiers
     source          1..221
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     Protein         1..221
                     /product="glutathione peroxidase 6"
                     /EC_number="1.11.1.9"
                     /calculated_mol_wt=24839
     CDS             1..221
                     /gene="GPX6"
                     /coded_by="NM_182701.1:51..716"
                     /selenocysteine
                     /db_xref="CCDS:CCDS43432.1"
                     /db_xref="GeneID:257202"
                     /db_xref="HGNC:4558"
                     /db_xref="HPRD:12132"
                     /db_xref="MIM:607913"
ORIGIN      
        1 mfqqfqascl vlfflvgfaq qtlkpqnrkv dcnkgvtgti yeygaltlng eeyiqfkqfa
       61 gkhvlfvnva ayuglaaqyp elnalqeelk nfgvivlafp cnqfgkqepg tnseillglk
      121 yvcpgsgfvp sfqlfekgdv ngekeqkvft flknscppts dllgsssqlf wepmkvhdir
      181 wnfekflvgp dgvpvmhwfh qapvstvksd ileylkqfnt h
//