LOCUS       NP_872630                137 aa            linear   PRI 22-OCT-2008
DEFINITION  ubiquitin-conjugating enzyme E2G 2 isoform 2 [Homo sapiens].
ACCESSION   NP_872630
VERSION     NP_872630.1  GI:33359701
DBSOURCE    REFSEQ: accession NM_182688.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 137)
  AUTHORS   Cao,J., Wang,J., Qi,W., Miao,H.H., Wang,J., Ge,L.,
            DeBose-Boyd,R.A., Tang,J.J., Li,B.L. and Song,B.L.
  TITLE     Ufd1 is a cofactor of gp78 and plays a key role in cholesterol
            metabolism by regulating the stability of HMG-CoA reductase
  JOURNAL   Cell Metab. 6 (2), 115-128 (2007)
   PUBMED   17681147
REFERENCE   2  (residues 1 to 137)
  AUTHORS   Ewing,R.M., Chu,P., Elisma,F., Li,H., Taylor,P., Climie,S.,
            McBroom-Cerajewski,L., Robinson,M.D., O'Connor,L., Li,M.,
            Taylor,R., Dharsee,M., Ho,Y., Heilbut,A., Moore,L., Zhang,S.,
            Ornatsky,O., Bukhman,Y.V., Ethier,M., Sheng,Y., Vasilescu,J.,
            Abu-Farha,M., Lambert,J.P., Duewel,H.S., Stewart,I.I., Kuehl,B.,
            Hogue,K., Colwill,K., Gladwish,K., Muskat,B., Kinach,R.,
            Adams,S.L., Moran,M.F., Morin,G.B., Topaloglou,T. and Figeys,D.
  TITLE     Large-scale mapping of human protein-protein interactions by mass
            spectrometry
  JOURNAL   Mol. Syst. Biol. 3, 89 (2007)
   PUBMED   17353931
REFERENCE   3  (residues 1 to 137)
  AUTHORS   Arai,R., Yoshikawa,S., Murayama,K., Imai,Y., Takahashi,R.,
            Shirouzu,M. and Yokoyama,S.
  TITLE     Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)
  JOURNAL   Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 (PT 4),
            330-334 (2006)
   PUBMED   16582478
  REMARK    GeneRIF: Structural comparison of human UBE2G2 with yeast Ubc7
            indicated that the overall structures are similar except for the
            long loop region and the C-terminal helix.
REFERENCE   4  (residues 1 to 137)
  AUTHORS   Chen,B., Mariano,J., Tsai,Y.C., Chan,A.H., Cohen,M. and
            Weissman,A.M.
  TITLE     The activity of a human endoplasmic reticulum-associated
            degradation E3, gp78, requires its Cue domain, RING finger, and an
            E2-binding site
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 103 (2), 341-346 (2006)
   PUBMED   16407162
  REMARK    GeneRIF: interrupting a specific E2-E3 interaction can selectively
            inhibit endoplasmic reticulum -associated degradation
REFERENCE   5  (residues 1 to 137)
  AUTHORS   Hu,Y.H., Warnatz,H.J., Vanhecke,D., Wagner,F., Fiebitz,A.,
            Thamm,S., Kahlem,P., Lehrach,H., Yaspo,M.L. and Janitz,M.
  TITLE     Cell array-based intracellular localization screening reveals novel
            functional features of human chromosome 21 proteins
  JOURNAL   BMC Genomics 7, 155 (2006)
   PUBMED   16780588
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 137)
  AUTHORS   Huang,L., Kinnucan,E., Wang,G., Beaudenon,S., Howley,P.M.,
            Huibregtse,J.M. and Pavletich,N.P.
  TITLE     Structure of an E6AP-UbcH7 complex: insights into ubiquitination by
            the E2-E3 enzyme cascade
  JOURNAL   Science 286 (5443), 1321-1326 (1999)
   PUBMED   10558980
REFERENCE   7  (residues 1 to 137)
  AUTHORS   Moynihan,T.P., Ardley,H.C., Nuber,U., Rose,S.A., Jones,P.F.,
            Markham,A.F., Scheffner,M. and Robinson,P.A.
  TITLE     The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with
            RING finger/IBR motif-containing domains of HHARI and H7-AP1
  JOURNAL   J. Biol. Chem. 274 (43), 30963-30968 (1999)
   PUBMED   10521492
REFERENCE   8  (residues 1 to 137)
  AUTHORS   Katsanis,N. and Fisher,E.M.
  TITLE     Identification, expression, and chromosomal localization of
            ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the
            Saccharomyces cerevisiae ubc7 gene
  JOURNAL   Genomics 51 (1), 128-131 (1998)
   PUBMED   9693041
REFERENCE   9  (residues 1 to 137)
  AUTHORS   Rose,S.A., Leek,J.P., Moynihan,T.P., Ardley,H.C., Markham,A.F. and
            Robinson,P.A.
  TITLE     Assignment1 of the ubiquitin conjugating enzyme gene, UBE2G2, to
            human chromosome band 21q22.3 by in situ hybridization
  JOURNAL   Cytogenet. Cell Genet. 83 (1-2), 98-99 (1998)
   PUBMED   9925943
REFERENCE   10 (residues 1 to 137)
  AUTHORS   Chen,P., Johnson,P., Sommer,T., Jentsch,S. and Hochstrasser,M.
  TITLE     Multiple ubiquitin-conjugating enzymes participate in the in vivo
            degradation of the yeast MAT alpha 2 repressor
  JOURNAL   Cell 74 (2), 357-369 (1993)
   PUBMED   8393731
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC001738.1, AF032456.1,
            BE292782.1 and BG702453.1.
            
            Summary: The modification of proteins with ubiquitin is an
            important cellular mechanism for targeting abnormal or short-lived
            proteins for degradation. Ubiquitination involves at least three
            classes of enzymes: ubiquitin-activating enzymes, or E1s,
            ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein
            ligases, or E3s. This gene encodes a member of the E2
            ubiquitin-conjugating enzyme family. The encoded protein shares
            100% sequence identity with the mouse counterpart. This gene is
            ubiquitously expressed, with high expression seen in adult muscle.
            Two alternatively spliced transcript variants encoding distinct
            isoforms have been found for this gene. [provided by RefSeq].
            
            Transcript Variant: This variant (2) has an additional exon in the
            5' region, as compared to variant 1. It uses a downstream start
            codon and encodes isoform 2 which has a shorter N-terminus, as
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..137
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     Protein         1..137
                     /product="ubiquitin-conjugating enzyme E2G 2 isoform 2"
                     /EC_number="6.3.2.19"
                     /note="ubiquitin-conjugating enzyme E2G 2 (homologous to
                     yeast UBC7); ubiquitin conjugating enzyme 7; ubiquitin
                     conjugating enzyme G2; ubiquitin carrier protein G2;
                     ubiquitin-protein ligase G2"
                     /calculated_mol_wt=15483
     CDS             1..137
                     /gene="UBE2G2"
                     /gene_synonym="UBC7"
                     /coded_by="NM_182688.1:275..688"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS33586.1"
                     /db_xref="GeneID:7327"
                     /db_xref="HGNC:12483"
                     /db_xref="HPRD:04387"
                     /db_xref="MIM:603124"
ORIGIN      
        1 mneenffewe alimgpedtc fefgvfpail sfpldyplsp pkmrftcemf hpniypdgrv
       61 cisilhapgd dpmgyessae rwspvqsvek illsvvsmla epndesganv daskmwrddr
      121 eqfykiakqi vqkslgl
//